The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome

被引：29

作者：

Malkin, D

Brown, EJ

Zipursky, A

机构：

[1] Hosp Sick Children, Div Hematol Oncol, Dept Pediat, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Toronto, ON, Canada

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 116卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(99)00072-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sequence analysis of the p53 tumor suppressor gene was performed on diagnostic blood and bone marrow samples from nine children with Down syndrome and acute megakaryoblastic leukemia. p53 sequence alterations were not observed in any of seven cases of transient leukemia; however, samples from two of three patients with acute megakaryoblastic leukemia harbored sequence alterations. The acquisition of both mutations (Gly245Val and Arg72Pro) in the transformation from transient leukemia to overt acute megakaryoblastic leukemia suggests a functional role of mutant p53 in the evolution of this disease. (C) Elsevier Science Inc., 1999. All rights reserved.

引用

页码：1 / 5

页数：5

共 42 条

[1]

BAKER SJ, 1990, CANCER RES, V50, P7717

[2]

BAKER SJ, 1990, SCIENCE, V249, P1912

[3]

BI SC, 1992, LEUKEMIA, V6, P839

[4] GROWTH-FACTOR MODULATION OF P53-MEDIATED GROWTH ARREST VERSUS APOPTOSIS [J].