Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell

被引：179

作者：

Peng-Zhang ^{[1
]}

Dai, Ke-rong ^{[2
]}

Yan, Shi-gui ^{[1
]}

Yan, Wei-qi ^{[1
]}

Chao-Zhang ^{[4
]}

Chen, De-qiang ^{[3
]}

Bo-Xu ^{[3
]}

Xu, Zhan-wang ^{[3
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthopaed, Hangzhou 310009, Zhejiang, Peoples R China

[2] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthopaed, Sch Med, Shanghai 200011, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Orthopaed, Jinan 250014, Shandong, Peoples R China

[4] Kun Hua Hosp, Kunming Med Coll, Dept Orthoped, Kunming 650032, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 607卷 / 1-3期

关键词：

Naringin; Rhizoma drynariae; Osteogenic differentiation; Human bone mesenchymal stem cell; DRYNARIAE-RHIZOMA EXTRACTS; INHIBITION; MANAGEMENT; TISSUE;

D O I：

10.1016/j.ejphar.2009.01.035

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Rhizoma drynariae is used commonly in the treatment of osteoporosis and bone nonunion in traditional Chinese medicine. Modern pharmacological research indicates that naringin is the main effective component of rhizoma drynariae, which can induce the expression of the osteogenic marker in the osteoblast cell line. However, no former study has described its effect on bone mesenchymal stem cells (BMSCs). In our experiment, we co-cultured human BMSCs with different concentrations of naringin solution, then the osteogenic differentiation markers and proliferation ability were analyzed. The results indicated that a certain concentration (1-100 mu g/ml) of the naringin solution may enhance the proliferation and osteogenic differentiation of human BMSCs. Also, our research explains excellently the anti-osteoporotic and bone nonunion treatment mechanism of rhizoma drynariae, thus contributing to the exploration of osteogenic differentiation agents from Chinese herbs. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

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