The role of Src family kinases in the normal and neoplastic gastrointestinal tract

被引：9

作者：

Banker, N ^{[1
]}

Evers, BM ^{[1
]}

Hellmich, MR ^{[1
]}

Townsend, CM ^{[1
]}

机构：

[1] UNIV TEXAS, MED BRANCH, DEPT SURG, GALVESTON, TX 77555 USA

来源：

SURGICAL ONCOLOGY-OXFORD | 1996年 / 5卷 / 5-6期

关键词：

Src kinase; gastrointestinal tract; neoplasms; growth; differentiation; SH2;

D O I：

10.1016/S0960-7404(96)80023-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.

引用

页码：201 / 210

页数：10

共 92 条

[1] ACTIVATION OF P56LCK THROUGH MUTATION OF A REGULATORY CARBOXY-TERMINAL TYROSINE RESIDUE REQUIRES INTACT SITES OF AUTOPHOSPHORYLATION AND MYRISTYLATION [J].

ABRAHAM, N ;

VEILLETTE, A .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) :5197-5206

[2]

ATFI A, 1994, J BIOL CHEM, V269, P30688

[3] THE HUMAN P50(CSK) TYROSINE KINASE PHOSPHORYLATES P56(LCK) AT TYR-505 AND DOWN REGULATES ITS CATALYTIC ACTIVITY [J].

BERGMAN, M ;

MUSTELIN, T ;

OETKEN, C ;

PARTANEN, J ;

FLINT, NA ;

AMREIN, KE ;

AUTERO, M ;

BURN, P ;

ALITALO, K .

EMBO JOURNAL, 1992, 11 (08) :2919-2924

[4] CELLULAR ONCOGENES AND RETROVIRUSES [J].

BISHOP, JM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :301-354

[5] MOLECULAR THEMES IN ONCOGENESIS [J].

BISHOP, JM .

CELL, 1991, 64 (02) :235-248

[6] ENHANCEMENT OF CELLULAR SRC GENE-PRODUCT ASSOCIATED TYROSYL KINASE-ACTIVITY FOLLOWING POLYOMA-VIRUS INFECTION AND TRANSFORMATION [J].

BOLEN, JB ;

THIELE, CJ ;

ISRAEL, MA ;

YONEMOTO, W ;

LIPSICH, LA ;

BRUGGE, JS .

CELL, 1984, 38 (03) :767-777

[7] ACTIVATION OF PP60C-SRC PROTEIN-KINASE ACTIVITY IN HUMAN-COLON CARCINOMA [J].

BOLEN, JB ;

VEILLETTE, A ;

SCHWARTZ, AM ;

DESEAU, V ;

ROSEN, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2251-2255

[8]

Brickell Paul M., 1992, Critical Reviews in Oncogenesis, V3, P401

[9]

BRUGGE JS, 1984, J BIOL CHEM, V259, P4550

[10] NEURONS EXPRESS HIGH-LEVELS OF A STRUCTURALLY MODIFIED, ACTIVATED FORM OF PP60C-SRC [J].

BRUGGE, JS ;

COTTON, PC ;

QUERAL, AE ;

BARRETT, JN ;

NONNER, D ;

KEANE, RW .

NATURE, 1985, 316 (6028) :554-557

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