Liposomal Bupivacaine A Comparative Study of More Than 1000 Total Joint Arthroplasty Cases

被引：49

作者：

Barrington, John W. ^{[1
]}

Olugbode, Oluseun ^{[2
]}

Lovald, Scott ^{[3
]}

Ong, Kevin ^{[4
]}

Watson, Heather ^{[3
]}

Emerson, Roger H., Jr. ^{[2
]}

机构：

[1] Plano Orthoped Sports Med & Spine Ctr, Plano, TX 75093 USA

[2] Texas Ctr Joint Replacement, Plano, TX 75093 USA

[3] Exponent Inc, Menlo Pk, CA 94025 USA

[4] Exponent Inc, Philadelphia, PA 19104 USA

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2015年 / 46卷 / 04期

关键词：

Liposomal bupivacaine; Knee arthroplasty; Hip arthroplasty; Pain control; Analgesia; TOTAL KNEE ARTHROPLASTY; PLACEBO-CONTROLLED TRIAL; EXTENDED PAIN RELIEF; ADVERSE DRUG EVENTS; QUALITY-OF-LIFE; POSTOPERATIVE PAIN; POSTSURGICAL-PAIN; DOUBLE-BLIND; TOTAL HIP; MANAGEMENT;

D O I：

10.1016/j.ocl.2015.06.003

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Pain after total joint arthroplasty (TJA) can be severe and difficult to control. A single-dose local analgesic delivers bupivacaine in a liposomal time-release platform. In 2248 consecutive patients with hip and knee arthroplasty, half (Pre) were treated using a well-established multimodal analgesia, including periarticular injection (PAI), and half had the PAI substituted for a liposomal bupivacaine injection technique (Post). Pain scores were significantly lower for patients in the Post group for both hip and knee procedures. A large series of patients who had TJA experienced pain relief after the introduction of liposomal bupivacaine as part of an established multimodal protocol.

引用

页码：469 / +

页数：10

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