Refractory Disseminated Coccidioidomycosis and Mycobacteriosis in Interferon-γ Receptor 1 Deficiency

被引：88

作者：

Vinh, Donald C. ^{[1
]}

Masannat, Fares ^{[2
,3
]}

Dzioba, Robert B. ^{[4
]}

Galgiani, John N. ^{[2
,3
]}

Holland, Steven M. ^{[1
]}

机构：

[1] NIAID, Immunopathogenesis Sect, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

[2] Univ Arizona, Coll Med, Valley Fever Ctr Excellence, Tucson, AZ USA

[3] So Arizona Vet Adm Hlth Care Syst, Tucson, AZ USA

[4] Univ Med Ctr, Tucson, AZ USA

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 06期

基金：

加拿大健康研究院;

关键词：

IFN-GAMMA; AUTOANTIBODIES; SUSCEPTIBILITY; TUBERCULOSIS; PATIENT; POLYMORPHISMS; ASSOCIATION; INFECTIONS; RESISTANCE; IMMITIS;

D O I：

10.1086/605532

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Severe coccidioidomycosis is rare, and specific genetic susceptibility to the disease remains unidentified. We describe a patient with disseminated recalcitrant coccidioidomycosis with autosomal dominant interferon-gamma receptor 1 deficiency caused by a heterozygous IFNGR1 818del4 mutation. Therefore, the interleukin-12/interferon-gamma axis appears to be critical for control of coccidioidomycosis.

引用

页码：E62 / E65

页数：4

共 22 条

[1] The complex immunology of human coccidioidomycosis [J].

Ampel, Neil M. .

COCCIDIOIDOMYCOSIS: SIXTH INTERNATIONAL SYMPOSIUM, 2007, 1111 :245-258

[2] SIGNIFICANCE OF T-CELLS IN RESISTANCE TO EXPERIMENTAL MURINE COCCIDIOIDOMYCOSIS [J].

BEAMAN, L ;

PAPPAGIANIS, D ;

BENJAMINI, E .

INFECTION AND IMMUNITY, 1977, 17 (03) :580-585

[3] MECHANISMS OF RESISTANCE TO INFECTION WITH COCCIDIOIDES-IMMITIS IN MICE [J].

BEAMAN, L ;

PAPPAGIANIS, D ;

BENJAMINI, E .

INFECTION AND IMMUNITY, 1979, 23 (03) :681-685

[4] Increased risk of coccidioidomycosis in patients treated with tumor necrosis factor α antagonists [J].

Bergstrom, L ;

Yocum, DE ;

Ampel, NM ;

Villanueva, I ;

Lisse, J ;

Gluck, O ;

Tesser, J ;

Posever, J ;

Miller, M ;

Araujo, J ;

Kageyama, DM ;

Berry, M ;

Karl, L ;

Yung, CM .

ARTHRITIS AND RHEUMATISM, 2004, 50 (06) :1959-1966

[5] From infectious diseases to primary immunodeficiencies [J].

Bustamante, Jacinta ;

Zhang, Shen-Ying ;

von Bernuth, Horst ;

Abel, Laurent ;

Casanova, Jean-Laurent .

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2008, 28 (02) :235-+

[6]

de Moraes-Vasconcelos D, 2005, CLIN INFECT DIS, V41, pE31, DOI 10.1086/432119

[7] Autoantibodies to interferon-γ in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity [J].

Döffinger, R ;

Helbert, MR ;

Barcenas-Morales, G ;

Yang, K ;

Dupuis, S ;

Ceron-Gutierrez, L ;

Espitia-Pinzon, C ;

Barnes, N ;

Bothamley, G ;

Casanova, JL ;

Longhurst, HJ ;

Kumararatne, DS .

CLINICAL INFECTIOUS DISEASES, 2004, 38 (01) :E10-E14

[8] HUMAN POLYMORPHONUCLEAR-LEUKOCYTE INHIBITION OF INCORPORATION OF CHITIN PRECURSORS INTO MYCELIA OF COCCIDIOIDES-IMMITIS [J].

GALGIANI, JN ;

PAYNE, CM ;

JONES, JF .

JOURNAL OF INFECTIOUS DISEASES, 1984, 149 (03) :404-412

[9] Naturally occurring anti-IFN-γ autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans [J].

Höflich, C ;

Sabat, R ;

Rosseau, S ;

Temmesfeld, B ;

Slevogt, H ;

Döcke, WD ;

Grütz, G ;

Meisel, C ;

Halle, E ;

Göbel, UB ;

Volk, HD ;

Suttorp, N .

BLOOD, 2004, 103 (02) :673-675

[10] Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ [J].

Kampmann, B ;

Hemingway, C ;

Stephens, A ;

Davidson, R ;

Goodsall, A ;

Anderson, S ;

Nicol, M ;

Schölvinck, E ;

Relman, D ;

Waddell, S ;

Langford, P ;

Sheehan, B ;

Semple, L ;

Wilkinson, KA ;

Wilkinson, RJ ;

Ress, S ;

Hibberd, M ;

Levin, M .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (09) :2480-2488

← 1 2 3 →