Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: Comparison of HPV risk group to cytology and histology

被引:31
作者
Castle, Philip E.
Sadorra, Mark
Garcia, Francisco
Holladay, E. Blair
Kornegay, Janet
机构
[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
[2] Roche Mol Syst, Alameda, CA USA
[3] Univ Arizona, Hlth Sci Ctr, Tucson, AZ 85721 USA
[4] Med Univ S Carolina, Charleston, SC USA
关键词
D O I
10.1128/JCM.01305-06
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (P-Trend < 0.0005) and histologic diagnoses (P-Trend < 0.0005).
引用
收藏
页码:3915 / 3917
页数:3
相关论文
共 15 条
  • [1] Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands
    Bulk, S
    Berkhof, J
    Bulkmans, NWJ
    Zielinski, GD
    Rozendaal, L
    van Kemenade, FJ
    Snijders, PJF
    Meijer, CJLM
    [J]. BRITISH JOURNAL OF CANCER, 2006, 94 (01) : 171 - 175
  • [2] Prevalence of types 16 and 33 is increased in high-risk human papillomavirus positive women with cervical intraepithelial neoplasia grade 2 or worse
    Bulkmans, NWJ
    Blecker, MCG
    Berkhof, J
    Voorhorst, FJ
    Snijders, PJF
    Meijer, CJLM
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (02) : 177 - 181
  • [3] Castle PE, 2002, CANCER EPIDEM BIOMAR, V11, P1394
  • [4] Worldwide distribution of human papillomavirus types in cytologically normal women in the international Agency for Research on Cancer HPV prevalence surveys:: a pooled analysis
    Clifford, GM
    Gallus, S
    Herrero, R
    Muñoz, N
    Snijders, PJF
    Vaccarella, S
    Anh, PTH
    Ferreccio, C
    Hieu, NT
    Matos, E
    Molano, M
    Rajkumar, R
    Ronco, G
    de Sanjosé, S
    Shin, HR
    Sukvirach, S
    Thomas, JO
    Tunsakul, S
    Meijer, CJLM
    Franceschi, S
    [J]. LANCET, 2005, 366 (9490) : 991 - 998
  • [5] Carcinogenicity of human papillomaviruses
    Cogliano, V
    Baan, R
    Straif, K
    Grosse, Y
    Secretan, B
    El Ghissassi, F
    [J]. LANCET ONCOLOGY, 2005, 6 (04) : 204 - 204
  • [6] Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method
    Gravitt, PE
    Peyton, CL
    Apple, RJ
    Wheeler, CM
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (10) : 3020 - 3027
  • [7] Gravitt PE, 2000, J CLIN MICROBIOL, V38, P357
  • [8] The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice
    Khan, MJ
    Castle, PE
    Lorincz, AT
    Wacholder, S
    Sherman, M
    Scott, DR
    Rush, BB
    Glass, AG
    Shiffman, M
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (14): : 1072 - 1079
  • [9] Evaluation of human papillomavirus testing in primary screening for cervical abnormalities - Comparison of sensitivity, specificity, and frequency of referral
    Kulasingam, SL
    Hughes, JP
    Kiviat, NB
    Mao, C
    Weiss, NS
    Kuypers, JM
    Koutsky, LA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (14): : 1749 - 1757
  • [10] HUMAN PAPILLOMAVIRUS INFECTION OF THE CERVIX - RELATIVE RISK ASSOCIATIONS OF 15 COMMON ANOGENITAL TYPES
    LORINCZ, AT
    REID, R
    JENSON, AB
    GREENBERG, MD
    LANCASTER, W
    KURMAN, RJ
    [J]. OBSTETRICS AND GYNECOLOGY, 1992, 79 (03) : 328 - 337