In vivo endomicroscopy improves detection of Barrett's esophagus-related neoplasia: a multicenter international randomized controlled trial (with video)

被引：129

作者：

Canto, Marcia Irene ^{[1
]}

Anandasabapathy, Sharmila ^{[2
]}

Brugge, William ^{[3
]}

Falk, Gary W. ^{[4
]}

Dunbar, Kerry B. ^{[5
]}

Zhang, Zhe ^{[6
]}

Woods, Kevin ^{[7
]}

Almario, Jose Antonio ^{[1
]}

Schell, Ursula ^{[8
]}

Goldblum, John ^{[9
]}

Maitra, Anirban ^{[10
]}

Montgomery, Elizabeth ^{[10
]}

Kiesslich, Ralf ^{[8
]}

机构：

[1] Johns Hopkins Med Inst, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA

[2] Mt Sinai Med Ctr, New York, NY 10029 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[4] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Univ Texas SW Med Ctr Dallas, Dallas Vet Affairs Med Ctr, Dallas, TX 75390 USA

[6] Johns Hopkins Med Inst, Dept Oncol, Div Biostat & Bioinformat, Baltimore, MD 21205 USA

[7] Emory Univ, Sch Med, Emory Univ Hosp, Atlanta, GA USA

[8] Johannes Gutenberg Univ Mainz, D-55122 Mainz, Germany

[9] Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA

[10] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

来源：

GASTROINTESTINAL ENDOSCOPY | 2014年 / 79卷 / 02期

关键词：

CONFOCAL LASER ENDOMICROSCOPY; HIGH-GRADE DYSPLASIA; SURGICAL-TREATMENT; ENDOSCOPY; MANAGEMENT; ADENOCARCINOMA; CLASSIFICATION; SURVEILLANCE; EFFICACY; BIOPSY;

D O I：

10.1016/j.gie.2013.09.020

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: Confocal laser endomicroscopy (CLE) enables in vivo microscopic imaging of the GI tract mucosa. However, there are limited data on endoscope-based CLE (eCLE) for imaging Barrett's esophagus (BE). Objective: To compare high-definition white-light endoscopy (HDWLE) alone with random biopsy (RB) and HDWLE + eCLE and targeted biopsy (TB) for diagnosis of BE neoplasia. Design: Multicenter, randomized, controlled trial. Setting: Academic medical centers. Patients: Adult patients with BE undergoing routine surveillance or referred for early neoplasia. Intervention: Patients were randomized to HDWLE + RB (group 1) or HDWLE + eCLE + TB (group 2). Real-time diagnoses and management plans were recorded after HDWLE in both groups and after eCLE in group 2. Blinded expert pathology diagnosis was the reference standard. Main Outcome Measurements: Diagnostic yield, performance characteristics, clinical impact. Results: A total of 192 patients with BE were studied. HDWLE + eCLE + TB led to a lower number of mucosal biopsies and higher diagnostic yield for neoplasia (34% vs 7%; < .0001), compared with HDWLE + RB but with comparable accuracy. HDWLE + eCLE + TB tripled the diagnostic yield for neoplasia (22% vs 6%; P = .002) and would have obviated the need for any biopsy in 65% of patients. The addition of eCLE to HDWLE increased the sensitivity for neoplasia detection to 96% from 40% (P < .0001) without significant reduction in specificity. In vivo CLE changed the treatment plan in 36% of patients. Limitations: Tertiary-care referral centers and expert endoscopists limit generalizability. Conclusion: Real-time eCLE and TB after HDWLE can improve the diagnostic yield and accuracy for neoplasia and significantly impact in vivo decision making by altering the diagnosis and guiding therapy. (Clinical trial registration number: NCT01124214.) (Gastrointest Endosc 2014; 79:211-21.)

引用

页码：211 / 221

页数：11

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