The paired-type homeobox gene Dmbx1 marks the midbrain and pretectum

被引：26

作者：

Gogoi, RN ^{[1
]}

Schubert, FR ^{[1
]}

Martinez-Barbera, JP ^{[1
]}

Acampora, D ^{[1
]}

Simeone, A ^{[1
]}

Lumsden, A ^{[1
]}

机构：

[1] Kings Coll London, MRC, Ctr Dev Neurobiol, London SE1 1UL, England

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 114卷 / 1-2期

关键词：

mouse; chick; isthmus; Atx; Dmbx1; stomodeal ectoderm; nasal pit; rhombencephalon;

D O I：

10.1016/S0925-4773(02)00067-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated a paired-type homeobox gene Dmbx1, previously known as Atx (Development 128 (2001) 4789), from chick and mouse. Sequence similarity reveals that this acne is highly related to the Otx genes. Expression of Dmbx1 commences during gastrulation, when transcripts are detected in a crescent around the anterior neural plate. As development progresses, Dmbx1 marks the prospective midbrain and pretectum. Dmbx1 shares its caudal border of expression with Otx2, while expression is sharply delimited rostrally by the synencephalic-parencephalic boundary, later becoming restricted to the posterior synencephalon. At later stages, Dmbx1 is expressed in dynamic domains of the hindbrain and spinal cord. Additional sites of expression comprise stomodeal ectoderm and foregut endoderm, presomitic mesoderm, and the nasal pit. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：213 / 217

页数：5

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