Traceless synthesis of benzimidazoles on solid support

被引：65

作者：

Mazurov, A ^{[1
]}

机构：

[1] NanoSyn Inc, Tucson, AZ 85747 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(99)00592-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Traceless solid-phase syntheses of benzimidazoles and 5-(benzimidazol-2-yl)benzimidazoles on 2-(4-formyl-3-methoxyphenoxy)ethyl polystyrene are described. No auxiliary functional groups are left in the products after ultimate cleavage and cyclization. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：67 / 70

页数：4

相关论文

共 15 条

[1] A parallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis [J].

AlMuhaimeed, H .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1997, 25 (04) :175-181

[2] Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality [J].

Boojamra, CG ;

Burow, KM ;

Thompson, LA ;

Ellman, JA .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (05) :1240-1256

[3] Solid-phase synthesis of diketopiperazines, useful scaffolds for combinatorial chemistry [J].

del Fresno, M ;

Alsina, J ;

Royo, M ;

Barany, G ;

Albericio, F .

TETRAHEDRON LETTERS, 1998, 39 (17) :2639-2642

[4] CLASS-III ANTIARRHYTHMIC ACTIVITY OF NOVEL SUBSTITUTED 4-[(METHYLSULFONYL)AMINO]BENZAMIDES AND SULFONAMIDES [J].

ELLINGBOE, JW ;

SPINELLI, W ;

WINKLEY, MW ;

NGUYEN, TT ;

PARSONS, RW ;

MOUBARAK, IF ;

KITZEN, JM ;

VONENGEN, D ;

BAGLI, JF .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (04) :705-716

[5] AMEBA: An acid sensitive aldehyde resin for solid phase synthesis [J].

Fivush, AM ;

Willson, TM .

TETRAHEDRON LETTERS, 1997, 38 (41) :7151-7154

[6] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED HIV PROTEINASE-INHIBITORS CONTAINING A STEREOCHEMICALLY UNIQUE PEPTIDE ISOSTERE [J].

HOLMES, DS ;

BETHELL, RC ;

CAMMACK, N ;

CLEMENS, IR ;

KITCHIN, J ;

MCMEEKIN, P ;

MO, CL ;

ORR, DC ;

PATEL, B ;

PATERNOSTER, IL ;

STORER, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (21) :3129-3136

[7] A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library [J].

Huang, WL ;

Scarborough, RM .

TETRAHEDRON LETTERS, 1999, 40 (14) :2665-2668

[8] Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles [J].

Lee, J ;

Gauthier, D ;

Rivero, RA .

TETRAHEDRON LETTERS, 1998, 39 (3-4) :201-204

[9] Solid-phase synthesis of benzimidazoles [J].

Mayer, JP ;

Lewis, GS ;

McGee, C ;

Bankaitis-Davis, D .

TETRAHEDRON LETTERS, 1998, 39 (37) :6655-6658

[10] Solid support synthesis of 2-substituted dibenz[b,f]oxazepin-11(10H)-ones via SNAr methodology on AMEBA resin. [J].

Ouyang, X ;

Tamayo, N ;

Kiselyov, AS .

TETRAHEDRON, 1999, 55 (10) :2827-2834