Colony-stimulating factor 1-dependent cells protect against systemic infection with Listeria monocytogenes but facilitate neuroinvasion

被引：18

作者：

Jin, YX

Dons, L

Kristensson, K

Rottenberg, ME

机构：

[1] Karolinska Inst, Microbiol & Tumorbiol Ctr, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

[3] Royal Vet & Agr Univ, Dept Vet Microbiol, DK-1870 Frederiksberg, Denmark

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 08期

关键词：

D O I：

10.1128/IAI.70.8.4682-4686.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By using mice genomically lacking the mononuclear phagocytic growth factor colony-stimulating factor I and thereby deficient in macrophage and dendritic cell populations, we show that these cells play a dual role: they constitute a major defense against systemic infection but also facilitate cerebral bacterial invasion by Listeria monocytogenes.

引用

收藏

页码：4682 / 4686

页数：5

相关论文

共 28 条

[1] Evidence for intraaxonal spread of Listeria monocytogenes from the periphery to the central nervous system [J].

Antal, EA ;

Loberg, EM ;

Bracht, P ;

Melby, KK ;

Mæhlen, J .

BRAIN PATHOLOGY, 2001, 11 (04) :432-438

[2] BACTEREMIA IS REQUIRED FOR INVASION OF THE MURINE CENTRAL-NERVOUS-SYSTEM BY LISTERIA-MONOCYTOGENES [J].

BERCHE, P .

MICROBIAL PATHOGENESIS, 1995, 18 (05) :323-336

[3] A gerbil model for rhombencephalitis due to Listeria monocytogenes [J].

Blanot, S ;

Joly, MM ;

Vilde, F ;

Jaubert, F ;

Clement, O ;

Frija, G ;

Berche, P .

MICROBIAL PATHOGENESIS, 1997, 23 (01) :39-48

[4]

CECCHINI MG, 1994, DEVELOPMENT, V120, P1357

[5]

Dramsi S, 1998, INFECT IMMUN, V66, P4461

[6] LISTERIA-MONOCYTOGENES INFECTS HUMAN ENDOTHELIAL-CELLS BY 2 DISTINCT MECHANISMS [J].

DREVETS, DA ;

SAWYER, RT ;

POTTER, TA ;

CAMPBELL, PA .

INFECTION AND IMMUNITY, 1995, 63 (11) :4268-4276

[7] Dissemination of Listeria monocytogenes by infected phagocytes [J].

Drevets, DA .

INFECTION AND IMMUNITY, 1999, 67 (07) :3512-3517

[8] Listeria monocytogenes-infected phagocytes can initiate central nervous system infection in mice [J].

Drevets, DA ;

Jelinek, TA ;

Freitag, NE .

INFECTION AND IMMUNITY, 2001, 69 (03) :1344-1350

[9]

ECK H, 1957, Schweiz Med Wochenschr, V87, P210

[10] Interaction of Listeria monocytogenes with human brain microvascular endothelial cells:: InlB-Dependent invasion, long-term intracellular growth, and spread from macrophages to endothelial cells [J].

Greiffenberg, L ;

Goebel, W ;

Kim, KS ;

Weiglein, I ;

Bubert, A ;

Engelbrecht, F ;

Stins, M ;

Kuhn, M .

INFECTION AND IMMUNITY, 1998, 66 (11) :5260-5267