Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats

被引：28

作者：

Lee, Hyunji ^{[1
]}

Choi, Hyeon-Son ^{[1
]}

Park, Yooheon ^{[1
]}

Ahn, Chang Won ^{[2
]}

Jung, Sung Ug ^{[2
]}

Park, Soo Hyun ^{[2
]}

Suh, Hyung Joo ^{[1
,3
]}

机构：

[1] Korea Univ, Dept Food & Nutr, Seoul, South Korea

[2] Nong Shim Co Ltd, Res & Dev Ctr, Seoul, South Korea

[3] Korea Univ, Dept Publ Hlth Sci, Program Embodiment Hlth Soc Interact BK21PLUS, Grad Sch, Seoul, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 10期

关键词：

matrix metalloproteinase; deer bone extract; tissue inhibitors of metalloproteinases; osteoarthritis; pro-inflammatory cytokines; CHONDROITIN SULFATE PROTEOGLYCAN; MATRIX METALLOPROTEINASES; II COLLAGEN; CHONDROCYTES; INTERLEUKIN-1-BETA; INHIBITORS; ANGIOGENESIS; STIMULATION; GLUCOSAMINE; HYDROLYSATE;

D O I：

10.1080/09168451.2014.930317

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Deer bone extract has the potential to relieve the discomfort or the articular cartilaginous damage associated with osteoarthritic (OA) and may be useful as a natural supplement for OA treatment without serious side effects. We analyzed the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced OA rats. Increases in the levels of serum pro-inflammatory cytokines, such as interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha were significantly inhibited by the administration of deer bone extract (p < 0.05). Decreases in the expression of collagen type II (COL2) and tissue inhibitors of metalloproteinases (TIMPs) mRNAs in the cartilage were significantly inhibited by deer bone extract treatment (p < 0.05). The deer bone extract significantly suppressed the expression of matrix metalloproteinases (MMPs) mRNAs in the cartilage. The deer bone extract induced the up-regulation of COL2 and TIMP mRNAs and the down-regulation of MMP mRNAs by suppressing the expression of pro-inflammatory cytokine mRNAs.

引用

页码：1703 / 1709

页数：7

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