Pathogenesis of adrenocortical incidentalomas and genetic syndromes associated with adrenocortical neoplasms

被引：24

作者：

Gicquel, C

Bertherat, J

Le Bouc, Y

Bertagna, X

机构：

[1] Hop Trousseau, Lab Explorations Fonctionnelles Endocriniennes, F-75571 Paris, France

[2] Univ Paris 05, Inst Cochin Genet Mol, Grp Etud Physiopathol Endocrinienne, Paris, France

[3] Reseau Rech Clin Comete, Paris, France

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2000年 / 29卷 / 01期

关键词：

D O I：

10.1016/S0889-8529(05)70112-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study of genetic syndromes associated with adrenocortical tumors (Beckwith-Wiedemann, Li-Fraumeni, McCune-Albright, Carney, and multiple endocrine neoplasia type 1) has shed light on the molecular basis of tumorigenesis. Abnormalities at the 11p15 locus appear as crucial and frequent events found specifically in malignant, sporadic tumors, leading to overexpression of a growth-promoting factor and loss of expression of tumor suppressor genes. In benign tumors, the cAMP pathway can be exacerbated in an ACTH-independent manner when various membrane receptors of the seven transmembrane superfamily are "illegitimately" expressed.

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页码：1 / +

页数：14

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