Effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility

被引：314

作者：

Wang, YX ^{[1
]}

Robertson, JL

Spillman, WB

Claus, RO

机构：

[1] Virginia Tech, Fiber & Electroopt Res Ctr, Blacksburg, VA 24061 USA

[2] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA

[3] Virginia Tech, Virginia Tech Appl Biosci Ctr, Blacksburg, VA 24061 USA

来源：

PHARMACEUTICAL RESEARCH | 2004年 / 21卷 / 08期

关键词：

biocompatibility; biomaterial; blood compatibility; cell adhesion; cytotoxicity; polymer; protein adsorption; surface property; tissue compatibility;

D O I：

10.1023/B:PHAM.0000036909.41843.18

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymeric biomaterials have extensively been used in medicinal applications. However, factors that determine their biocompatibility are still not very clear. This article reviews various effects of the chemical structure and the surface properties of polymeric biomaterials on their biocompatibility, including protein adsorption, cell adhesion, cytotoxicity, blood compatibility, and tissue compatibility. Understanding these aspects of biocompatibility is important to the improvement of the biocompatibility of existing polymers and the design of new biocompatible polymers.

引用

页码：1362 / 1373

页数：12

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