More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

被引：63

作者：

Khan, Nufail ^{[1
,2
]}

Lawlor, Kate E. ^{[1
,2
]}

Murphy, James M. ^{[1
,2
]}

Vince, James E. ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3050, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 26卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; NONAPOPTOTIC CELL-DEATH; MIXED LINEAGE KINASE; INTERACTING PROTEIN RIP; CHAIN ASSEMBLY COMPLEX; ISCHEMIC BRAIN-INJURY; TNF-INDUCED NECROSIS; PROGRAMMED NECROSIS; FACTOR-ALPHA;

D O I：

10.1016/j.coi.2013.10.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Necroptosis describes a pro-inflammatory form of cell death governed by the kinases RIP1 and RIP3. Necroptosis can occur following stimulation of the DNA receptor, DAI, or activation of death receptor, Toll-like receptor, T-cell antigen receptor, or interferon receptor signaling. Analysis of RIP3 deficient mice has implicated necroptosis in several inflammatory-driven diseases, including atherosclerosis, alcoholic liver disease and retinal degeneration. Although studies have demonstrated that mixed lineage kinase domain-like (MLK'L) is the only substrate of RIP3 kinase that is essential for necroptotic death, the molecular determinants acting downstream of MLKL remain ambiguous. In addition, RIP3 can signal necroptosis independent of RIP1, may induce apoptosis, and can directly promote pro-inflammatory cytokine production. Therefore it will be important to determine if non-necroptotic RIP3 signaling influences RIP3 dependent pathologies.

引用

页码：76 / 89

页数：14

共 137 条

[1] FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells [J].

Bell, Bryan D. ;

Leverrier, Sabrina ;

Weist, Brian M. ;

Newton, Ryan H. ;

Arechiga, Adrian F. ;

Luhrs, Keith A. ;

Morrissette, Naomi S. ;

Walsh, Craig M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (43) :16677-16682

[2] cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination [J].

Bertrand, Mathieu J. M. ;

Milutinovic, Snezana ;

Dickson, Kathleen M. ;

Ho, Wai Chi ;

Boudreault, Alain ;

Durkin, Jon ;

Gillard, John W. ;

Jaquith, James B. ;

Morris, Stephen J. ;

Barker, Philip A. .

MOLECULAR CELL, 2008, 30 (06) :689-700

[3] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation [J].

Bonnet, Marion C. ;

Preukschat, Daniela ;

Welz, Patrick-Simon ;

van Loo, Geert ;

Ermolaeva, Maria A. ;

Bloch, Wilhelm ;

Haase, Ingo ;

Pasparakis, Manolis .

IMMUNITY, 2011, 35 (04) :572-582

[4] ENDOTOXIN-INDUCED SERUM FACTOR THAT CAUSES NECROSIS OF TUMORS [J].

CARSWELL, EA ;

OLD, LJ ;

KASSEL, RL ;

GREEN, S ;

FIORE, N ;

WILLIAMSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (09) :3666-3670

[5] Antigen-mediated T cell expansion regulated by parallel pathways of death [J].

Ch'en, Irene L. ;

Beisner, Daniel R. ;

Degterev, Alexei ;

Lynch, Candace ;

Yuan, Junying ;

Hoffmann, Alexander ;

Hedrick, Stephen M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17463-17468

[6] Mechanisms of necroptosis in T cells [J].

Ch'en, Irene L. ;

Tsau, Jennifer S. ;

Molkentin, Jeffery D. ;

Komatsu, Masaaki ;

Hedrick, Stephen M. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (04) :633-641

[7] Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling [J].

Chen, Wanze ;

Zhou, Zhenru ;

Li, Lisheng ;

Zhong, Chuan-Qi ;

Zheng, Xinru ;

Wu, Xiurong ;

Zhang, Yingying ;

Ma, Huan ;

Huang, Deli ;

Li, Wenjuan ;

Xia, Zongping ;

Han, Jiahuai .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (23) :16247-16261

[8] Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation [J].

Cho, YoungSik ;

Challa, Sreerupa ;

Moquin, David ;

Genga, Ryan ;

Ray, Tathagat Dutta ;

Guildford, Melissa ;

Chan, Francis Ka-Ming .

CELL, 2009, 137 (06) :1112-1123

[9] A novel role for RIP1 kinase in mediating TNFα production [J].

Christofferson, D. E. ;

Li, Y. ;

Hitomi, J. ;

Zhou, W. ;

Upperman, C. ;

Zhu, H. ;

Gerber, S. A. ;

Gygi, S. ;

Yuan, J. .

CELL DEATH & DISEASE, 2012, 3 :e320-e320

[10] Rip1 mediates the Trif-dependent Toll-like receptor 3- and 4-induced NF-κB activation but does not contribute to interferon regulatory factor 3 activation [J].

Cusson-Hermance, N ;

Khurana, S ;

Lee, TH ;

Fitzgerald, KA ;

Kelliher, MA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (44) :36560-36566

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