Chemokine RANTES promoter polymorphisms in allergic rhinitis

被引：21

作者：

Kim, JJ

Lee, JH ^{[1
]}

Jang, CH

Kim, YS

Chae, SC

Chung, HT

Choi, TW

Lee, JH ^{[1
]}

机构：

[1] Wonkwang Univ, Sch Med, Dept Otolaryngol, Wonkwang Inst Med Sci, Chonbuk 570749, South Korea

[2] Wonkwang Univ, Sch Med, Dept Anat, Wonkwang Inst Med Sci, Chonbuk 570749, South Korea

[3] Wonkwang Univ, Sch Med, Dept Microbiol & Immunol, Wonkwang Inst Med Sci, Chonbuk 570749, South Korea

[4] Wonkwang Univ, Sch Med, Genom Res Ctr Immune Disorders, Wonkwang Inst Med Sci, Chonbuk 570749, South Korea

来源：

LARYNGOSCOPE | 2004年 / 114卷 / 04期

关键词：

RANTES; allergic rhinitis; polymorphism; Korean;

D O I：

10.1097/00005537-200404000-00013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objectives/Hypothesis: RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (-403 G/A and -28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis. Study Design: Case-control study. Methods: Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction-based assays for detection of the -403 G/A and -28 C/G polymorphisms of the RANTES gene were used for genotyping. Results: The frequencies of both the RANTES -403A and -28G alleles were significantly higher in patients with allergic rhinitis than in control subjects (P < .05 for both). Conclusion: The study results indicated that the -403 and -28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis.

引用

页码：666 / 669

页数：4

共 17 条

[1] The-403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma [J].