Facile cleavage of carbohydrate benzyl ethers and benzylidene acetals using the NaBrO3/Na2S2O4 reagent under two-phase conditions

被引：88

作者：

Adinolfi, M ^{[1
]}

Barone, G ^{[1
]}

Guariniello, L ^{[1
]}

Iadonisi, A ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Chim Organ & Biol, I-80134 Naples, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 48期

关键词：

cleavage reactions; carbohydrates;

D O I：

10.1016/S0040-4039(99)01756-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzyl ether and benzylidene acetal carbohydrate protecting groups can be selectively cleaved by reaction with sodium bromate/sodium dithionite in ethyl acetate/water. Under the mild (room temperature, short reaction time) conditions needed, a variety of other protecting functionalities such as acetyl, chloroacetyl, benzoyl, pivaloyl, tosyl, t-butyldimethylsilyl, trityl, and isopropylidene groups remain unaffected. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8439 / 8441

页数：3

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