The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice

被引：36

作者：

Yamada, J ^{[1
]}

Sugimoto, Y ^{[1
]}

Ujikawa, M ^{[1
]}

机构：

[1] Kobe Pharmaceut Univ, Dept Pharmacol, Higashinada Ku, Kobe, Hyogo 6588558, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 383卷 / 01期

关键词：

leptin; 5-hydroxytryptophan (5-HTP); 5-HT; (5-hydroxytryptamine; serotonin); carbidopa; (mouse);

D O I：

10.1016/S0014-2999(99)00580-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a serotonin (5-MT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. 5-HTP dose dependently increased serum leptin levels in mice. Pretreatment of the peripheral aromatic amino acid decarboxylase inhibitor carbidopa suppressed 5-HTP-induced hyperleptinemia. These results suggest that the secretion of leptin may be modified by serotonergic mechanisms. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：49 / 51

页数：3

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