Anti-tumor activities of matrine and oxymatrine: literature review

被引：328

作者：

Liu, Yan ^{[1
,3
]}

Xu, Yang ^{[2
]}

Ji, Weidan ^{[2
]}

Li, Xiaoya ^{[2
]}

Sun, Bin ^{[2
]}

Gao, Quangen ^{[1
,3
]}

Su, Changqing ^{[2
]}

机构：

[1] Wujiang 1 Peoples Hosp, Dept Gen Surg, Suzhou 215200, Peoples R China

[2] Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Mol Oncol, Shanghai 200438, Peoples R China

[3] Xuzhou Med Coll, Grad Sch, Xuzhou 221004, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Matrine; Oxymatrine; Anticancer activity; Molecular mechanism; CELLS IN-VITRO; NF-KAPPA-B; COMPOUND KUSHEN INJECTION; PANCREATIC-CANCER; INHIBITS PROLIFERATION; METABOLITE MATRINE; HUMAN PLASMA; APOPTOSIS; EXPRESSION; AUTOPHAGY;

D O I：

10.1007/s13277-014-1680-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of Sophora species, have various pharmacological activities and are demonstrated to have anti-inflammatory, anti-allergic, anti-virus, anti-fibrotic, and cardiovascular protective effects. They are recently proved to have anti-cancer potentials, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- or radiotherapy-induced toxicity when combined with other chemotherapeutic drugs. In this review, we summarize the recent investigations regarding the anti-cancer activities and possible molecular targets of MT and OMT for cancer prevention and treatment in order to provide clues and references for further study.

引用

页码：5111 / 5119

页数：9

共 95 条

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[2]

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