Antagonists of the P2X7 Receptor. From Lead Identification to Drug Development

被引：126

作者：

Guile, Simon D. ^{[1
]}

Alcaraz, Lilian ^{[1
]}

Birkinshaw, Timothy N. ^{[1
]}

Bowers, Keith C. ^{[2
]}

Ebden, Mark R. ^{[1
]}

Furber, Mark ^{[1
]}

Stocks, Michael J. ^{[1
]}

机构：

[1] AstraZeneca R&D Charnwood, Dept Med Chem, Loughborough LE11 5RH, Leics, England

[2] AstraZeneca R&D Charnwood, Dept Biosci, Loughborough LE11 5RH, Leics, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 52卷 / 10期

关键词：

IN-VITRO ACTIVITY; POTENT ANTAGONIST; INTERLEUKIN-1-BETA RELEASE; BIOLOGICAL-ACTIVITY; NEUROPATHIC PAIN; ATP RECEPTOR; P2; RECEPTORS; DISCOVERY; PURINOCEPTOR; MATURATION;

D O I：

10.1021/jm801528x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3123 / 3141

页数：19

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