The Human K-Complex Represents an Isolated Cortical Down-State

被引：261

作者：

Cash, Sydney S. ^{[1
]}

Halgren, Eric ^{[2
,3
,4
]}

Dehghani, Nima ^{[2
,3
,4
]}

Rossetti, Andrea O. ^{[7
]}

Thesen, Thomas ^{[5
]}

Wang, ChunMao ^{[5
]}

Devinsky, Orrin ^{[5
]}

Kuzniecky, Ruben ^{[5
]}

Doyle, Werner ^{[5
]}

Madsen, Joseph R. ^{[6
]}

Bromfield, Edward ^{[7
]}

Eross, Lorand ^{[8
]}

Halasz, Peter ^{[9
,11
]}

Karmos, George ^{[10
,11
]}

Csercsa, Richard ^{[10
]}

Wittner, Lucia ^{[8
,10
]}

Ulbert, Istvan ^{[8
,10
,11
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol,Epilepsy Div, Boston, MA 02114 USA

[2] Univ Calif San Diego, Dept Radiol, San Diego, CA 92093 USA

[3] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA

[4] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA

[5] NYU, Sch Med, Comprehens Epilepsy Ctr, New York, NY 10016 USA

[6] Childrens Hosp, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Boston, MA 02115 USA

[8] Natl Inst Neurosurg, H-1145 Budapest, Hungary

[9] Epilepsy Ctr, Natl Inst Psychiat & Neurol, H-1145 Budapest, Hungary

[10] Hungarian Acad Sci, Inst Psychol, H-1394 Budapest, Hungary

[11] Peter Pazmany Catholic Univ, Dept Informat Technol, H-1083 Budapest, Hungary

来源：

SCIENCE | 2009年 / 324卷 / 5930期

关键词：

SLOW-WAVE SLEEP; NEOCORTICAL NEURONS; NETWORK MECHANISMS; OSCILLATION; MODEL; HZ;

D O I：

10.1126/science.1169626

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The electroencephalogram (EEG) is a mainstay of clinical neurology and is tightly correlated with brain function, but the specific currents generating human EEG elements remain poorly specified because of a lack of microphysiological recordings. The largest event in healthy human EEGs is the K-complex (KC), which occurs in slow-wave sleep. Here, we show that KCs are generated in widespread cortical areas by outward dendritic currents in the middle and upper cortical layers, accompanied by decreased broadband EEG power and decreased neuronal firing, which demonstrate a steep decline in network activity. Thus, KCs are isolated "down-states," a fundamental cortico-thalamic processing mode already characterized in animals. This correspondence is compatible with proposed contributions of the KC to sleep preservation and memory consolidation.

引用

页码：1084 / 1087

页数：4

共 27 条

[1]

Amzica F, 1998, NEUROSCIENCE, V82, P671

[2] The K-complex: Its slow (<1-Hz) rhythmicity and relation to delta waves [J].

Amzica, F ;

Steriade, M .

NEUROLOGY, 1997, 49 (04) :952-959

[3]

Bazhenov M, 2002, J NEUROSCI, V22, P8691

[4]

Buzaki G., 2006, Rhythms of the Brain, DOI 10.1093/acprof:oso/9780195301069.001.0001

[5] The K-complex: A 7-decade history [J].

Colrain, IM .

SLEEP, 2005, 28 (02) :255-273

[6] Cellular and network mechanisms of slow oscillatory activity (<1 Hz) and wave propagations in a cortical network model [J].

Compte, A ;

Sanchez-Vives, MV ;

McCormick, DA ;

Wang, XJ .

JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (05) :2707-2725

[7] Mechanisms of long lasting hyperpolarizations underlying slow sleep oscillations in cat corticothalamic networks [J].

Contreras, D ;

Timofeev, I ;

Steriade, M .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 494 (01) :251-264

[8] Control of spatiotemporal coherence of a thalamic oscillation by corticothalamic feedback [J].

Contreras, D ;

Destexhe, A ;

Sejnowski, TJ ;

Steriade, M .

SCIENCE, 1996, 274 (5288) :771-774

[9] Neuronal metabolism governs cortical network response state [J].

Cunningham, MO ;

Pervouchine, DD ;

Racca, C ;

Kopell, NJ ;

Davies, CH ;

Jones, RSG ;

Traub, RD ;

Whittington, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (14) :5597-5601

[10] K-complex, a reactive EEG graphoelement of NREM sleep:: an old chap in a new garment [J].

Halász, P .

SLEEP MEDICINE REVIEWS, 2005, 9 (05) :391-412

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