Gene therapy in the cardiovascular system: an update

被引：28

作者：

Sinnaeve, P

Varenne, O

Collen, D

Janssens, S

机构：

[1] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

[2] Katholieke Univ Leuven, Hosp Gasthuisberg, Cardiac Unit, Louvain, Belgium

[3] Hop Bichat Claude Bernard, Cardiac Unit, F-75877 Paris, France

来源：

CARDIOVASCULAR RESEARCH | 1999年 / 44卷 / 03期

关键词：

atherosclerosis; gene therapy; heart failure; hypertension; infection/inflammation; thrombosis/embolism;

D O I：

10.1016/S0008-6363(99)00259-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This update reviews the remarkable progression in several cardiovascular gene transfer domains. The first chemical gene therapy protocols to stimulate angiogenesis in ischemic myocardium are discussed and both the great expectations as well as remaining hurdles are highlighted. In experimental models of restenosis and heart failure gene therapy shows promising results. Important questions regarding vector-related limitations and suboptimal in vivo delivery systems will require expeditious attention for gene therapy to become a more widely applicable option in cardiovascular diseases. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：498 / 506

页数：9

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