Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase.

被引：106

作者：

Wakasugi, K

Slike, BM

Hood, J

Ewalt, KL

Cheresh, DA

Schimmel, P

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

[5] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2002年 / 277卷 / 23期

关键词：

D O I：

10.1074/jbc.C200126200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first step of protein synthesis is catalyzed by aminoacyl-tRNA synthetases. In addition, certain mammalian tRNA synthetases link protein synthesis to cytokine signaling pathways. In particular, human tyrosyl-tRNA synthetase (TyrRS) can be split by proteolysis into two fragments having distinct cytokine activities. One of the TyrRS fragments (mini TyrRS) contains features identical to those in CXC chemokines (like interleukin-8) that also act as angiogenic factors. Here mini TyrRS (but not full-length TyrRS) is shown to stimulate chemotaxis of endothelial cells in vitro and stimulate angiogenesis in each of two in vivo animal models. The angiogenic activity of mini TyrRS can be opposed by anti-angiogenic chemokines like IP-10. Thus, a biological fragment of human tyrosyl-tRNA synthetase links protein synthesis to regulation of angiogenesis.

引用

收藏

页码：20124 / 20126

页数：3

相关论文

共 34 条

[1] The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity [J].

Addison, CL ;

Daniel, TO ;

Burdick, MD ;

Liu, H ;

Ehlert, JE ;

Xue, YY ;

Buechi, L ;

Walz, A ;

Richmond, A ;

Strieter, RM .

JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :5269-5277

[2] The CXC chemokines growth-regulated oncogene (GRO) alpha, GRO beta, GRO gamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor [J].

Ahuja, SK ;

Murphy, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) :20545-20550

[3] The role of CXC chemokines in the regulation of angiogenesis in non-small cell lung cancer [J].

Arenberg, DA ;

Polverini, PJ ;

Kunkel, SL ;

Shanafelt, A ;

Hesselgesser, J ;

Horuk, R ;

Strieter, RM .

JOURNAL OF LEUKOCYTE BIOLOGY, 1997, 62 (05) :554-562

[4] Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases [J].

Arenberg, DA ;

Kunkel, SL ;

Polverini, PJ ;

Morris, SB ;

Burdick, MD ;

Glass, MC ;

Taub, DT ;

Iannettoni, MD ;

Whyte, TI ;

Strieter, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :981-992

[5]

Belperio JA, 2000, J LEUKOCYTE BIOL, V68, P1

[6]

Brooks PC, 1999, METH MOL B, V129, P257

[7] Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity [J].

Brooks, PC ;

Silletti, S ;

von Schalscha, TL ;

Friedlander, M ;

Cheresh, DA .

CELL, 1998, 92 (03) :391-400

[8] INTEGRIN ALPHA(V)BETA(3) ANTAGONISTS PROMOTE TUMOR-REGRESSION BY INDUCING APOPTOSIS OF ANGIOGENIC BLOOD-VESSELS [J].

BROOKS, PC ;

MONTGOMERY, AMP ;

ROSENFELD, M ;

REISFELD, RA ;

HU, TH ;

KLIER, G ;

CHERESH, DA .

CELL, 1994, 79 (07) :1157-1164

[9]

CLARKLEWIS I, 1991, J BIOL CHEM, V266, P23128

[10] PLATELET FACTOR-IV BINDS TO INTERLEUKIN-8 RECEPTORS AND ACTIVATES NEUTROPHILS WHEN ITS N-TERMINUS IS MODIFIED WITH GLU-LEU-ARG [J].

CLARKLEWIS, I ;

DEWALD, B ;

GEISER, T ;

MOSER, B ;

BAGGIOLINI, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3574-3577

← 1 2 3 4 →