Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases

被引：228

作者：

Hafizi, Sassan ^{[1
]}

Dam, Bjorn ^{[1
]}

机构：

[1] Lund Univ, Univ Hosp Malmo, Wallenberg Lab, Dept Clin Chem, SE-20502 Malmo, Sweden

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 04期

关键词：

Axl; Gas6; receptor tyrosine kinase; vitamin K; cell survival;

D O I：

10.1016/j.cytogfr.2006.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The related Axl, Sky and Mer receptor tyrosine kinases (RTKs) are increasingly being implicated in a host of discrete cellular responses including cell survival, proliferation, migration and phagocytosis. Furthermore, their ligands Gas6 and protein S are characteristically dependent on vitamin K for expression of their functions. The Gas6/Axl system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Each member of the Axl RTK subfamily possesses distinct expression profiles as well as discrete functions. In this article, we review the knowledge so far on the intracellular signalling interactions and pathways concerning each of the Axl RTKs. In this way, we hope to gain a greater understanding of the mechanisms that set each of them apart, and that relay their associated functions. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：295 / 304

页数：10

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