Immunotherapy as a means to induce transplantation tolerance

被引：33

作者：

Adler, SH ^{[1
]}

Turka, LA ^{[1
]}

机构：

[1] Univ Penn, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(02)00376-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There have been several recent advances in the use of immunotherapy to induce transplantation tolerance. These include newer and safer protocols to create hematopoietic chimerism, the development of more-powerful T cell depleting antibodies, the identification of additional costimlulatory pathways as molecular targets and the identification of a role for suppressor cells in transplant tolerance.

引用

页码：660 / 665

页数：6

共 49 条

[1] Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression [J].

Adams, AB ;

Durham, MM ;

Kean, L ;

Shirasugi, N ;

Ha, JW ;

Williams, MA ;

Rees, PA ;

Cheung, MC ;

Mittelstaedt, S ;

Bingaman, AW ;

Archer, DR ;

Pearson, TC ;

Waller, EK ;

Larsen, CP .

JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :1103-1111

[2] Analysis of primate renal allografts after T-cell depletion with anti-CD3-CRM9 [J].

Armstrong, N ;

Buckley, P ;

Oberley, T ;

Fechner, J ;

Dong, YC ;

Hong, XN ;

Kirk, A ;

Neville, D ;

Knechtle, S .

TRANSPLANTATION, 1998, 66 (01) :5-13

[3] CD40 ligand (CD154) triggers a short-term CD4+ T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis [J].

Blair, PJ ;

Riley, JL ;

Harlan, DM ;

Abe, R ;

Tadaki, DK ;

Hoffmann, SC ;

White, L ;

Francomano, T ;

Perfetto, SJ ;

Kirk, AD ;

June, CH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :651-660

[4]

CENDALES LC, 2002, AM J TRANSPLANTAT, V2, pA960

[5]

Dai ZH, 1998, J IMMUNOL, V161, P1659

[6]

Dumont F J, 2001, Curr Opin Investig Drugs, V2, P139

[7] Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioning [J].

Fändrich, F ;

Lin, XB ;

Chai, GX ;

Schulze, M ;

Ganten, D ;

Bader, M ;

Holle, J ;

Huang, DS ;

Parwaresch, R ;

Zavazava, N ;

Binas, B .

NATURE MEDICINE, 2002, 8 (02) :171-178

[8] Campath-1H monoclonal antibody therapy [J].

Flynn, JM ;

Byrd, JC .

CURRENT OPINION IN ONCOLOGY, 2000, 12 (06) :574-581

[9] An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow [J].

George, JF ;

Sweeney, SD ;

Kirklin, JK ;

Simpson, EM ;

Goldstein, DR ;

Thomas, JM .

NATURE MEDICINE, 1998, 4 (03) :333-335

[10] Strategies for making more organs available for transplantation [J].

Gridelli, B ;

Remuzzi, G .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (06) :404-410

← 1 2 3 4 5 →