Cloning and expression of the murine sws/NTE gene

被引:48
作者
Moser, M
Stempfl, T
Li, Y
Glynn, P
Büttner, R
Kretzschmar, D
机构
[1] Univ Regensburg, Inst Pathol, D-93053 Regensburg, Germany
[2] Univ Regensburg, Lehrstuhl Entwicklungsbiol, D-93053 Regensburg, Germany
[3] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
关键词
Drosophila swiss-cheese; mouse swiss-cheese; neuropathy target esterase; neurodegeneration; gene expression; nervous system;
D O I
10.1016/S0925-4773(99)00239-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Drosophila neurodegeneration gene swiss-cheese encodes a neuronal protein apparently involved in glia-neuron interaction and is homologous to human NTE, the molecular target of organophosphate-induced neuropathy. The isolated Msws/NTE gene is 96% identical to NTE. During development the Msws transcript is expressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia. Postnatally, Msws mRNA is expressed in all brain areas, with an increasingly restrictive pattern, In adult mice expression is most prominent in Purkinje cells. granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pens. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:279 / 282
页数:4
相关论文
共 7 条
[1]   Neuropathy target esterase: Immunolocalization to neuronal cell bodies and axons [J].
Glynn, P ;
Holton, JL ;
Nolan, CC ;
Read, DJ ;
Brown, L ;
Hubbard, A ;
Cavanagh, JB .
NEUROSCIENCE, 1998, 83 (01) :295-302
[2]  
JOHNSON MK, 1982, REV BIOCHEM TOXICOL, V4, P141
[3]  
Kretzschmar D, 1997, J NEUROSCI, V17, P7425
[4]   THE PATHOGENESIS OF ORGANOPHOSPHATE POLYNEUROPATHY [J].
LOTTI, M .
CRITICAL REVIEWS IN TOXICOLOGY, 1992, 21 (06) :465-487
[5]  
Lush MJ, 1998, BIOCHEM J, V332, P1
[6]  
MOSER M, 1995, DEVELOPMENT, V121, P2779
[7]  
Sambrook J., 2002, MOL CLONING LAB MANU