Drug interactions

被引：37

作者：

Boobis, Alan ^{[1
]}

Watelet, Jean-Baptiste ^{[2
]}

Whomsley, Rhys ^{[3
]}

Benedetti, Margherita Strolin ^{[4
]}

Demoly, Pascal ^{[5
]}

Tipton, Keith ^{[6
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Med, Dept Expt Med & Toxicol, London W2O NN, England

[2] Univ Ghent, State Univ Ghent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Ghent, Belgium

[3] Shire Pharmaceut, Biosci, Basingstoke, Hants, England

[4] UCB Pharma SA, F-92705 Colombes, France

[5] Univ Hosp Montpellier, Hosp Amaud Villeneuve, INSERM, U657, F-34295 Montpellier 5, France

[6] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

来源：

DRUG METABOLISM REVIEWS | 2009年 / 41卷 / 03期

关键词：

Drug-drug interactions; drug-diet interactions; P450; transporters; enzyme induction; enzyme inhibition; dietary amines; PREGNANE-X-RECEPTOR; HUMAN LIVER-MICROSOMES; AMINE OXIDASE SSAO; ST-JOHNS-WORT; VITRO CYTOCHROME-P450 INHIBITION; FLAVIN-CONTAINING MONOOXYGENASES; HISTIDINE-DECARBOXYLASE GENE; MECHANISM-BASED INACTIVATION; ISCHEMIA-REPERFUSION INJURY; IMMORTALIZED FA2N-4 CELLS;

D O I：

10.1080/10837450902891550

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug-diet interactions. The potential for metabolism-based drug interactions is increasingly being taken into account during drug development, using a variety of in silico and in vitro approaches. Prediction of transporter-based interactions is not as advanced. The clinical importance of a drug interaction will depend upon a number of factors, and it is important to address concerns quantitatively, taking into account the therapeutic index of the compound.

引用

页码：486 / 527

页数：42

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