The diabetogenic effects of acute verapamil poisoning

被引:45
作者
Kline, JA [1 ]
Raymond, RM [1 ]
Schroeder, JD [1 ]
Watts, JA [1 ]
机构
[1] BROWN UNIV, DEPT EMERGENCY MED, PROVIDENCE, RI 02903 USA
关键词
D O I
10.1006/taap.1997.8195
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Verapamil poisoning is known to produce hyperglycemia and metabolic acidosis in humans. The purpose of this study was to elucidate mechanisms of verapamil-induced hyperglycemia in awake dogs. Mongrel canines were chronically instrumented to permit studies in the conscious state, In six healthy dogs, steady-state glucose infusion requirement after 1 hr of insulin infusion at 1000 mU/min was 19 +/- 1 mg/kg/min. In six separate dogs, verapamil toxicity was induced via verapamil infusion in the portal vein; during verapamil toxicity, the glucose infusion requirement with an insulin infusion rate of 1000 mU/min was significantly decreased (3 +/- 1 mg/kg/min; p < 0.05, unpaired t test). Eleven other verapamil-toxic dogs were also treated with either saline (n = 6, 3.0 ml/kg/hr) or glucagon (n = 5, 10 mu g/kg/min). Insulin concentrations were not changed vs basal concentrations in either group. Catecholamine concentrations increased at least 15-fold in all groups (from 458 +/- 169 to 6973 +/- 480 pg/L in the saline-treated group). Glucose concentrations increased in saline-treated animals from 3.7 +/- 0.3 to 11.2 +/- 1.0 mu mol/L, and with glucagon treatment, increased from 3.3 +/- 0.3 to 16.1 +/- 1.6 mu mol/L (p < 0.05 vs saline, ANOVA). Verapamil poisoning appears to produce hyperglycemia by inducing systemic insulin resistance, blocking insulin release, together with an intact stress hormone response and glucogenic capacity, (C) 1997 Academic Press.
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页码:357 / 362
页数:6
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