Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

被引：846

作者：

Bu, Guojun ^{[1
,2
]}

机构：

[1] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, Dept Pediat, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2009年 / 10卷 / 05期

关键词：

DENSITY-LIPOPROTEIN RECEPTOR; AMYLOID PRECURSOR PROTEIN; CENTRAL-NERVOUS-SYSTEM; BETA-PEPTIDE DEPOSITION; KNOCK-IN MICE; A-BETA; TRANSGENIC MICE; CELL-SURFACE; APOE ISOFORM; MOUSE MODEL;

D O I：

10.1038/nrn2620

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is probably influenced by both genetic and environmental risk factors. A strong genetic risk factor for late-onset AD is the presence of the epsilon 4 allele of the apolipoprotein E (APOE) gene, which encodes a protein with crucial roles in cholesterol metabolism. There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-beta peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors. Emerging knowledge of the contribution of APOE to the pathophysiology of AD presents new opportunities for AD therapy.

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收藏

页码：333 / 344

页数：12

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