Effects of estrogen and nonylphenol on the post-transcriptional regulation of vitellogenin gene expression

被引:44
作者
Ren, LF
Lewis, SK
Lech, JJ
机构
[1] Dept. of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226
关键词
estrogen; vitellogenin; nonylphenol; post-transcriptional regulation; precursor mRNA; RNA splicing; RT-PCR; DNA sequencing;
D O I
10.1016/0009-2797(95)03686-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Estrogenic chemicals have drawn considerable attention over the past several years because they are known to be responsible for increased breast and prostate cancer [1,2]. Vitellogenin expression driven by estrogen has been becoming a model for studying estrogenic effects in aquatic species. For the first time, we showed evidence that, without stimulation, vitellogenin mRNA precursor is expressed in both male and female immature fish. After 4 h, in fish treated with estradiol, the vitellogenin mRNA was synthesized and the precursor mRNA began to disappear. The environmental chemical, nonylphenol, showed the same effect on the vitellogenin gene expression as estrogen, It is suggested that estrogen and nonylphenol may be involved in a post-transcriptional regulation process - possibly in the initiation of pre-mRNA splicing.
引用
收藏
页码:67 / 76
页数:10
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