Severely reduced female fertility in CD9-deficient mice

被引：528

作者：

Le Naour, F ^{[1
]}

Rubinstein, E ^{[1
]}

Jasmin, C ^{[1
]}

Prenant, M ^{[1
]}

Boucheix, C ^{[1
]}

机构：

[1] Hop Paul Brousse, INSERM, U 268, F-94800 Villejuif, France

来源：

SCIENCE | 2000年 / 287卷 / 5451期

关键词：

D O I：

10.1126/science.287.5451.319

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins. The tetraspanins CD9, KAI-1/CD82, and CD63 are involved in metastasis suppression, an effect that may be related to their association with beta 1 integrins. Knockout mice lacking CD9 were created to evaluate the physiological importance of CD9. CD9(-/-) females displayed a severe reduction of fertility. Oocytes were ovulated but were not successfully fertilized because sperm did not fuse with the oocytes from CD9(-/-) females. Thus, CD9 appears to be essential for sperm-egg fusion, a process involving the CD9-associated integrin alpha 6 beta 1.

引用

页码：319 / 321

页数：3

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