Paired inhibitory and triggering NK cell receptors for HLA class I molecules

被引:96
作者
López-Botet, M [1 ]
Bellón, T [1 ]
Llano, M [1 ]
Navarro, F [1 ]
García, P [1 ]
de Miguel, M [1 ]
机构
[1] Hosp Univ Princesa, Serv Inmunol, Madrid 28006, Spain
关键词
natural killer cell; HLA; receptor; KIR; CD94;
D O I
10.1016/S0198-8859(99)00161-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human natural killer (NK) cells specifically interact with major histocompatibility complex (MHC) class I molecules employing different receptor systems, shared with subsets of alpha beta and gamma delta T lymphocytes. Killer cell immunoglobulin-like receptors (KIRs) recognize groups of human leukocyte antigen (HLA) class Ia proteins displaying common structural features at the alpha-1 domain; among them, KIR2DL4 has been proposed to specifically interact with the class Ib molecule HLA-G1. Members of a related family of immunoglobulin (Ig)-like receptors (ILT2 or LIR-1 and ILT4 or LIR-2), expressed by other leukocyte lineages, interact with a broad spectrum of class Ia molecules and HLA-G1. On the other hand, CD94/NKG2-A(-C) and NKG2D lectin-like receptors, respectively, recognize the class Ib molecules HLA-E and MICA. A recurrent finding within the different receptor families is the existence of pairs of homologous molecules that often share the same ligands but display divergent functions. Inhibitory receptors rend to exhibit an affinity for HLA molecules higher than their activating counterparts. Recruitment of SH2 domain-bearing tyrosine phosphatases (SHP) by cytoplasmic phosphorylated immunoreceptor tyrosine-based inhibition motifs (ITIMs) is a crucial event for the inhibitory signalling pathway. By contrast, triggering receptors assemble with homodimers of immune tyrosine-based activation motif (ITAM)-bearing adaptor molecules (i.e., DAP12, CD3 zeta) that engage tyrosine kinases (ZAP70 and syk). Human Immunology 61, 7-17 (2000). (C) American Society for Histocompatibility and Immunogenetics, 2000. Published by Elsevier Science Inc.
引用
收藏
页码:7 / 17
页数:11
相关论文
共 130 条
[1]  
Agrawal S, 1999, J IMMUNOL, V162, P1223
[2]   IDENTIFICATION OF A TAP-DEPENDENT LEADER PEPTIDE RECOGNIZED BY ALLOREACTIVE T-CELLS SPECIFIC FOR A CLASS IB ANTIGEN [J].
ALDRICH, CJ ;
DECLOUX, A ;
WOODS, AS ;
COTTER, RJ ;
SOLOSKI, MJ ;
FORMAN, J .
CELL, 1994, 79 (04) :649-658
[3]   Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells [J].
Allan, DSJ ;
Colonna, M ;
Lanier, LL ;
Churakova, TD ;
Abrams, JS ;
Ellis, SA ;
McMichael, AJ ;
Braud, VM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1149-1155
[4]  
André P, 1999, EUR J IMMUNOL, V29, P1076, DOI 10.1002/(SICI)1521-4141(199904)29:04<1076::AID-IMMU1076>3.0.CO
[5]  
2-Z
[6]   The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b [J].
Bai, A ;
Broen, J ;
Forman, J .
IMMUNITY, 1998, 9 (03) :413-421
[7]  
Bakker ABH, 1998, J IMMUNOL, V160, P5239
[8]   Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily [J].
Banham, AH ;
Colonna, M ;
Cella, M ;
Micklem, KJ ;
Pulford, K ;
Willis, AC ;
Mason, DY .
JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 65 (06) :841-845
[9]   Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].
Bauer, Stefan ;
Groh, Veronika ;
Wu, Jun ;
Steinle, Alexander ;
Phillips, Joseph H. ;
Lanier, Lewis L. ;
Spies, Thomas .
JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233
[10]  
Bellón T, 1999, J IMMUNOL, V162, P3996