Flaxseed for Hypertension: Implications for Blood Pressure Regulation

被引:44
作者
Caligiuri, Stephanie P. B. [1 ,2 ,3 ]
Edel, Andrea L. [1 ,2 ,3 ]
Aliani, Michel [1 ,4 ]
Pierce, Grant N. [1 ,2 ,3 ]
机构
[1] St Boniface Hosp Res Ctr, Canadian Ctr Agrifood Res Hlth & Med CCARM, Winnipeg, MB R2H 2A6, Canada
[2] St Boniface Hosp Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB, Canada
[3] Univ Manitoba, Dept Physiol, Winnipeg, MB, Canada
[4] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB, Canada
关键词
Dietary flaxseed; Anti-hypertensive therapy; Blood pressure regulation; Alpha-linolenic acid; Lignans; Enterolignans; Enterolactone; Enterodiol; ALPHA-LINOLENIC-ACID; RANDOMIZED CONTROLLED-TRIAL; DIETARY FIBER INTAKE; LIGNAN COMPLEX; LIPID PROFILE; SECOISOLARICIRESINOL DIGLUCOSIDE; DOUBLE-BLIND; FATTY-ACID; ENTEROLACTONE; PROTEIN;
D O I
10.1007/s11906-014-0499-8
中图分类号
R6 [外科学];
学科分类号
100210 [外科学];
摘要
Hypertension is the single largest risk factor attributed to mortality in the world. Medications are the primary treatment for hypertension; however, adherence to drug regimens is low (similar to 50 %). Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. An effective alternative or complement to medications in managing hypertension is through lifestyle modifications. Adopting a healthy diet is a valuable strategy. A recent, randomized controlled year-long trial observed impressive reductions in blood pressure in patients with hypertension consuming flaxseed daily. Therefore, attention has been garnered for flaxseed as a potentially valuable strategy for the management of hypertension. This review will highlight the recent data for flaxseed and its extracts in blood pressure regulation in both animal models and clinical trials. Insight into the proposed anti-hypertensive mechanism of flaxseed and the implications of flaxseed as a potential global anti-hypertensive therapy will be discussed.
引用
收藏
页码:1 / 13
页数:13
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