Identification of a bioactive compound isolated from Brazilian propolis type 6

被引：57

作者：

Castro, Myrella Lessio ^{[1
]}

do Nascimento, Andrea Mendes ^{[2
]}

Ikegaki, Masaharu ^{[3
]}

Costa-Neto, Claudio M. ^{[4
]}

Alencar, Severino M. ^{[2
]}

Rosalen, Pedro L. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Physiol Sci, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, Brazil

[2] Univ Sao Paulo, Dept Agri Food Ind Food & Nutr, Luiz de Queiroz Coll Agr, BR-13418900 Piracicaba, SP, Brazil

[3] Univ Fed Alfenas, Dept Pharm, BR-37130000 Alfenas, MG, Brazil

[4] Univ Sao Paulo, Dept Biochem & Immunol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 14期

基金：

巴西圣保罗研究基金会;

关键词：

Prenylated benzophenone hyperibone A; Brazilian propolis; Biological activity; ANTIBACTERIAL ACTIVITY; MUTANS STREPTOCOCCI; POLYISOPRENYLATED BENZOPHENONE; BIOLOGICAL-ACTIVITY; CUBAN PROPOLIS; APIS-MELLIFERA; CLUSIA-ROSEA; DERIVATIVES; CONSTITUENTS; NEMOROSONE;

D O I：

10.1016/j.bmc.2009.04.066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 mu M), strong antimicrobial activity (MIC range-0.73-6.6 mu g/mL; MBC range-2.92-106 mu g/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5332 / 5335

页数：4

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