Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-γ receptor loci

被引：86

作者：

Kanagawa, O

Xu, G

Tevaarwerk, A

Vaupel, BA

机构：

[1] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA

来源：

JOURNAL OF IMMUNOLOGY | 2000年 / 164卷 / 07期

关键词：

D O I：

10.4049/jimmunol.164.7.3919

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonobese diabetic (NOD) mice carrying a segment of chromosome Ranking the disrupted IFN-gamma receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-gamma R-deficient genotype from the diabetes-resistant phenotype, These results indicate that the protection of NOD mice from the development of diabetes is not directly linked to the defective IFN-gamma receptor gene but, rather, is influenced by the presence of a diabetes-resistant gene(s) closely linked to the IFN-gamma R loci derived from the 129 mouse strain.

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页码：3919 / 3923

页数：5

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