Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RME-ras cells

被引：13

作者：

Kim, SA

Kim, HW

Kim, DK

Kim, SG

Park, JC

Kang, DW

Kim, SW

Ahn, SG

Yoon, JH

机构：

[1] Chosun Univ, Coll Dent, Dept Pathol, Oral Biol Res Inst,BK Project 21, Kwangju 501759, South Korea

[2] Chosun Univ, Coll Engn, Dept Environm Engn, Kwangju 501759, South Korea

来源：

CANCER LETTERS | 2006年 / 235卷 / 01期

关键词：

RK3E; k-ras; tumor model; Sprague-Dawley rat;

D O I：

10.1016/j.canlet.2005.04.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RME-ras). We observed tumor as early its 3 days after injection of RME-ras cells in subcutaneous of Sprague-Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：53 / 59

页数：7

共 23 条

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