Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma

被引：62

作者：

van Baarle, D

Wolthers, KC

Hovenkamp, E

Niesters, HGM

Osterhaus, ADME

Miedema, F

van Oers, MHJ

机构：

[1] CLB, Dept Clin Viro Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Rotterdam Hosp, Dept Virol, Rotterdam, Netherlands

来源：

JOURNAL OF INFECTIOUS DISEASES | 2002年 / 186卷 / 03期

关键词：

D O I：

10.1086/341460

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To study whether Epstein-Barr virus (EBV) load can be used to predict the occurrence of acquired immunodeficiency syndrome-related non-Hodgkin lymphoma (AIDS-NHL), we determined EBV load longitudinally for individuals infected with human immunodeficiency virus type 1. EBV load in peripheral blood mononuclear cells (PBMC) was high and displayed considerable fluctuations over time, indicating that absolute EBV load in PBMC is not predictive of the development of AIDS-NHL. EBV DNA was also detectable in serum at some time points but at a lower level.

引用

页码：405 / 409

页数：5

共 17 条

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Bai X, 1997, CLIN CHEM, V43, P1843

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