Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies

被引：498

作者：

Anderson, Kristin G. ^{[1
,2
,3
,4
]}

Stromnes, Ingunn M. ^{[1
,2
]}

Greenberg, Philip D. ^{[1
,2
,3
,4
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Mail Stop D3-100,POB 19024, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Program Immunol, Seattle, WA 98109 USA

[3] Univ Washington, Sch Med, Dept Med Oncol, Seattle, WA 98109 USA

[4] Univ Washington, Sch Med, Dept Immunol, Seattle, WA 98109 USA

来源：

CANCER CELL | 2017年 / 31卷 / 03期

关键词：

FATTY-ACID SYNTHASE; HUMAN PANCREATIC-CANCER; FOCAL ADHESION KINASE; WNT/BETA-CATENIN PATHWAY; INDOLEAMINE 2,3-DIOXYGENASE; ANTITUMOR-ACTIVITY; ONCOGENIC KRAS; INTERLEUKIN-8; EXPRESSION; PROGNOSTIC-SIGNIFICANCE; RECEPTOR EXPRESSION;

D O I：

10.1016/j.ccell.2017.02.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

T cell dysfunction in solid tumors results from multiple mechanisms. Altered signaling pathways in tumor cells help produce a suppressive tumor microenvironment enriched for inhibitory cells, posing a major obstacle for cancer immunity. Metabolic constraints to cell function and survival shape tumor progression and immune cell function. In the face of persistent antigen, chronic T cell receptor signaling drives T lymphocytes to a functionally exhausted state. Here we discuss how the tumor and its microenvironment influences T cell trafficking and function with a focus on melanoma, and pancreatic and ovarian cancer, and discuss how scientific advances may help overcome these hurdles.

引用

页码：311 / 325

页数：15

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