Cholesterol-phospholipid interactions, the liquid-ordered phase and lipid rafts in model and biological membranes

被引：287

作者：

McMullen, TPW ^{[1
]}

Lewis, RNAH ^{[1
]}

McElhaney, RN ^{[1
]}

机构：

[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2004年 / 8卷 / 06期

基金：

加拿大健康研究院;

关键词：

cholesterol-phospholipid interactions; liquid-ordered phase and lipid rafts; model and biological membranes;

D O I：

10.1016/j.cocis.2004.01.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The existence of relatively large and long-lived detergent-insoluble, sphingolipid- and cholesterol-enriched, liquid-ordered lipid raft domains in the plasma membranes of eukaryotic cells has become widely accepted. However, we believe that the evidence for their existence is not compelling despite extensive work on both lipid bilayer model and biological membranes. We review here the results of recent studies, which in our view call into question the existence of lipid rafts in membranes, at least in the form commonly depicted. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：459 / 468

页数：10

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