Fluorinated natural products with clinical significance

被引：33

作者：

Thomas, Craig J. ^{[1
]}

机构：

[1] NIDDK, NIH, Chem Biol Core, Bethesda, MD 20892 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 14期

关键词：

natural products; fluorine; camptothecin; artemisinin; Vinca alkaloids; taxanes; epothilones;

D O I：

10.2174/156802606777951109

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The modification of natural products in an effort to alter their biochemical capacity is a common technique utilized by synthetic and medicinal chemists. Fluorine substitution imparts unique and advantageous physiochemical properties that can be shrewdly employed to constructively alter pharmacological agents. The adornment of natural products with fluorine has proven beneficial in several examples. This overview discusses several of the most relevant fluorinated natural products under current examination.

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页码：1529 / 1543

页数：15

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