Mesenchymal stem cells: Isolation and therapeutics

被引：363

作者：

Alhadlaq, A

Mao, JJ

机构：

[1] Univ Illinois, Dept Anat & Cell Biol, Tissue Engn Lab MC 841, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA

[3] Univ Illinois, Dept Orthodont, Chicago, IL 60612 USA

来源：

STEM CELLS AND DEVELOPMENT | 2004年 / 13卷 / 04期

关键词：

D O I：

10.1089/1547328041797552

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cells (MSCs) are progenitors of all connective tissue cells. In adults of multiple vertebrate species, MSCs have been isolated from bone marrow ( BM) and other tissues, expanded in culture, and differentiated into several tissue-forming cells such as bone, cartilage, fat, muscle, tendon, liver, kidney, heart, and even brain cells. Recent advances in the practical end of application of MSCs toward regeneration of a human-shaped articular condyle of the synovial joint is one example of their functionality and versatility. The present review not only outlines several approaches relevant to the isolation and therapeutic use of MSCs, but also presents several examples of phenotypic and functional characterization of isolated MSCs and their progeny.

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收藏

页码：436 / 448

页数：13

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