共 64 条
The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
被引:20
作者:

Barlocco, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy

Cignarella, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy

Giardina, GAM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy

Toma, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy
机构:
[1] Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy
[2] SmithKline Beecham SpA, Dept Med Chem, I-20021 Milan, Italy
[3] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy
关键词:
analgesia;
opioid-receptor-like 1 (ORL-1);
nociceptin;
orphanin FQ;
D O I:
10.1016/S0223-5234(00)00126-4
中图分类号:
R914 [药物化学];
学科分类号:
100701 ;
摘要:
A new sequence, which encoded a novel G protein-coupled receptor, was disclosed by two different groups, using the nucleic acid probes based on the delta opioid receptor, first cloned in 1992. The new receptor, which Meunier called opioid-receptor-like 1 (ORL-1), was shown to share high homology with the opioid receptors and therefore thought to be a potential target for new analgesics. In this respect, the present review reports on the literature referring to ORL-1, to its natural ligand (nociceptin or orphanin FQ) and to several synthetic analogues recently described, both as agonists or antagonists at the receptor. (C) 2000 Editions scientifiques er medicales Elsevier SAS.
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页码:275 / 282
页数:8
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共 64 条
- [1] Relationship between binding affinity and functional activity of nociceptin/orphanin FQ[J]. NEUROPEPTIDES, 1997, 31 (05) : 403 - 408Adapa, ID论文数: 0 引用数: 0 h-index: 0机构: SRI INT,DEPT NEUROSCI,MENLO PK,CA 94025 SRI INT,DEPT NEUROSCI,MENLO PK,CA 94025Toll, L论文数: 0 引用数: 0 h-index: 0机构: SRI INT,DEPT NEUROSCI,MENLO PK,CA 94025 SRI INT,DEPT NEUROSCI,MENLO PK,CA 94025
- [2] Ligands for κ-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial library[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (39) : 27513 - 27522Becker, JAJ论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceWallace, A论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceGarzon, A论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceIngallinella, P论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceBianchi, E论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceCortese, R论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceSimonin, F论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FranceKieffer, BL论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, FrancePessi, A论文数: 0 引用数: 0 h-index: 0机构: Ecole Super Biotechnol Strasbourg, F-67400 Illkirch Graffenstaden, France
- [3] Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 321 (01) : 97 - 103Butour, JL论文数: 0 引用数: 0 h-index: 0机构: CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCEMoisand, C论文数: 0 引用数: 0 h-index: 0机构: CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCEMazarguil, H论文数: 0 引用数: 0 h-index: 0机构: CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCEMollereau, C论文数: 0 引用数: 0 h-index: 0机构: CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCEMeunier, JC论文数: 0 引用数: 0 h-index: 0机构: CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE CNRS,UPR 9062,INST PHARMACOL & BIOL STRUCT,UNITE NEUROPHARMACOL MOL,F-31077 TOULOUSE,FRANCE
- [4] [Phe1ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 349 (01) : R5 - R6Butour, JL论文数: 0 引用数: 0 h-index: 0机构: Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, France Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, FranceMoisand, C论文数: 0 引用数: 0 h-index: 0机构: Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, France Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, FranceMollereau, C论文数: 0 引用数: 0 h-index: 0机构: Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, France Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, FranceMeunier, JC论文数: 0 引用数: 0 h-index: 0机构: Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, France Inst Pharmacol & Biol Struct, CNRS, UPR 9062, Unite Neuropharmacol Mol, F-31077 Toulouse 4, France
- [5] The mouse vas deferens: A pharmacological preparation sensitive to nociceptin[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 311 (01) : R3 - R5Calo, G论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYRizzi, A论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYBogoni, G论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYNeugebauer, V论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYSalvadori, S论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYGuerrini, R论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYBianchi, C论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALYRegoli, D论文数: 0 引用数: 0 h-index: 0机构: UNIV FERRARA,INST PHARMACOL,I-44100 FERRARA,ITALY
- [6] Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (02) : 373 - 378Calò, G论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, Italy Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyRizzi, A论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyMarzola, G论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyGuerrini, R论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, Italy论文数: 引用数: h-index:机构:Beani, L论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyRegoli, D论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, ItalyBianchi, C论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dept Expt & Clin Med, Pharmacol Sect, I-44100 Ferrara, Italy
- [7] Structure-activity study of the nociceptin(1-13)-NH2 N-terminal tetrapeptide and discovery of a nociceptin receptor antagonist[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) : 3360 - 3366Calo', G论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalyGuerrini, R论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalyBigoni, R论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalyRizzi, A论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalyBianchi, C论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalyRegoli, D论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, ItalySalvadori, S论文数: 0 引用数: 0 h-index: 0机构: Univ Ferrara, Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
- [8] Evidence that [Phe1 ψ (CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1998, 125 (05) : 949 - 951Carpenter, KJ论文数: 0 引用数: 0 h-index: 0机构: Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, England Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, EnglandDickenson, AH论文数: 0 引用数: 0 h-index: 0机构: Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, England Univ London Univ Coll, Dept Pharmacol, London WC1E 6BT, England
- [9] The orphanin FQ system: an emerging target for the management of pain?[J]. BRITISH JOURNAL OF ANAESTHESIA, 1998, 81 (01) : 29 - 37Darland, T论文数: 0 引用数: 0 h-index: 0机构: Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USAGrandy, DK论文数: 0 引用数: 0 h-index: 0机构: Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA
- [10] Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain[J]. LIFE SCIENCES, 1996, 59 (01) : PL23 - PL29Dooley, CT论文数: 0 引用数: 0 h-index: 0机构: TORREY PINES INST MOL STUDIES,SAN DIEGO,CA 92121 TORREY PINES INST MOL STUDIES,SAN DIEGO,CA 92121Houghten, RA论文数: 0 引用数: 0 h-index: 0机构: TORREY PINES INST MOL STUDIES,SAN DIEGO,CA 92121 TORREY PINES INST MOL STUDIES,SAN DIEGO,CA 92121