The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics

被引:20
作者
Barlocco, D
Cignarella, G
Giardina, GAM
Toma, L
机构
[1] Univ Milan, Ist Chim Farmaceut & Tossicol, I-20131 Milan, Italy
[2] SmithKline Beecham SpA, Dept Med Chem, I-20021 Milan, Italy
[3] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy
关键词
analgesia; opioid-receptor-like 1 (ORL-1); nociceptin; orphanin FQ;
D O I
10.1016/S0223-5234(00)00126-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new sequence, which encoded a novel G protein-coupled receptor, was disclosed by two different groups, using the nucleic acid probes based on the delta opioid receptor, first cloned in 1992. The new receptor, which Meunier called opioid-receptor-like 1 (ORL-1), was shown to share high homology with the opioid receptors and therefore thought to be a potential target for new analgesics. In this respect, the present review reports on the literature referring to ORL-1, to its natural ligand (nociceptin or orphanin FQ) and to several synthetic analogues recently described, both as agonists or antagonists at the receptor. (C) 2000 Editions scientifiques er medicales Elsevier SAS.
引用
收藏
页码:275 / 282
页数:8
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