The thiazolidinedione insulin sensitiser, BRL 49653, increases the expression of PPAR-gamma and aP(2) in adipose tissue of high-fat-fed rats

被引：69

作者：

Pearson, SL ^{[1
]}

Cawthorne, MA ^{[1
]}

Clapham, JC ^{[1
]}

Dunmore, SJ ^{[1
]}

Holmes, SD ^{[1
]}

Moore, GBT ^{[1
]}

Smith, SA ^{[1
]}

Tadayyon, M ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 229卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.1876

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of the thiazolidinedione insulin sensitiser BRL 49653 on plasma leptin concentrations and on epididymal fat OB, PPAR-gamma and aP(2) mRNA expression were examined in high-fat-fed and high-carbohydrate-fed adult Wistar rats. Diets were given for 4 weeks, with BRL 49653 (10 mu mol/kg/day) administered by oral gavage for the last 4 days. Treatment with BRL 49653 reduced plasma leptin concentrations in high-fat-fed rats from 2.34 +/- 0.19 (n=9) to 1.42 +/- 0.09 (n=9) ng/ml (p<0.001). Plasma leptin was unaffected by BRL 49653 in the high-carbohydrate-fed rats. There was no difference in OB mRNA expression between high-fat-fed and high-carbohydrate-fed rats, with or without treatment. PPAR-gamma and aP(2) mRNA expression were significantly increased in the high-fat-fed rats treated with BRL 49653 (p<0.01 and p<0.001 respectively), but not in carbohydrate-fed rats. (C) 1996 Academic Press

引用

页码：752 / 757

页数：6

共 23 条

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