Telomeres in Molecular Epidemiology Studies

被引：21

作者：

Bodelon, Clara ^{[1
]}

Savage, Sharon A. ^{[1
]}

Gadalla, Shahinaz M. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

来源：

TELOMERES IN HEALTH AND DISEASE | 2014年 / 125卷

关键词：

CARDIOVASCULAR-DISEASE; CANCER-RISK; CIGARETTE-SMOKING; LENGTH DYNAMICS; SOUTHERN BLOTS; BUCCAL CELLS; IN-SITU; BREAST; ASSOCIATION; AGE;

D O I：

10.1016/B978-0-12-397898-1.00005-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the role that these genetic structures have in disease risk and mortality in human populations. This chapter provides an overview of the current telomere epidemiology research and discusses approaches taken in these investigations. We also highlight important methodological considerations that may affect data interpretation.

引用

页码：113 / 131

页数：19

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