Genomic sequence and evolution of marine cyanophage P60: a new insight on lytic and lysogenic phages

被引：132

作者：

Chen, F

Lu, JR

机构：

[1] Univ Maryland, Biotechnol Inst, Ctr Marine Biotechnol, Baltimore, MD 21202 USA

[2] Univ Georgia, Dept Marine Sci, Athens, GA 30602 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2002年 / 68卷 / 05期

关键词：

D O I：

10.1128/AEM.68.5.2589-2594.2002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genome of cyanophage P60, a lytic virus which infects marine Synechococcus WH7803, was completely sequenced. The P60 genome contained 47,872 bp with 80 potential open reading frames that were mostly similar to the genes found in lytic phages like T7, phi-YeO3-12, and SIOL The DNA replication system, consisting of primase-helicase and DNA polymerase, appeared to be more conserved in podoviruses than in siphoviruses and myoviruses, suggesting that DNA replication genes could be the critical elements for lytic phages. Strikingly high sequence similarities in the regions coding for nucleotide metabolism were found between cyanophage P60 and marine unicellular cyanobacteria.

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页码：2589 / 2594

页数：6

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