A gut-vascular barrier controls the systemic dissemination of bacteria

被引：608

作者：

Spadoni, Ilaria ^{[1
]}

Zagato, Elena ^{[1
]}

Bertocchi, Alice ^{[1
]}

Paolinelli, Roberta ^{[2
]}

Hot, Edina ^{[1
]}

Di Sabatino, Antonio ^{[3
]}

Caprioli, Flavio ^{[4
,5
]}

Bottiglieri, Luca ^{[6
]}

Oldani, Amanda ^{[2
]}

Viale, Giuseppe ^{[6
]}

Penna, Giuseppe ^{[1
]}

Dejana, Elisabetta ^{[2
,7
,8
]}

Rescigno, Maria ^{[1
,7
]}

机构：

[1] European Inst Oncol, Dept Expt Oncol, Milan, Italy

[2] Italian Fdn Canc Res FIRC, Inst Mol Oncol IFOM, Milan, Italy

[3] Univ Pavia, St Matteo Hosp, Dept Med 1, I-27100 Pavia, Italy

[4] Osped Maggiore Policlin Milano, Fdn IRCCS Ca Granda, Unita Operat Gastroenterol & Endoscopia, Milan, Italy

[5] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Milan, Italy

[6] European Inst Oncol, Dept Pathol & Lab Med, Milan, Italy

[7] Univ Milan, Dept Biosci, I-20122 Milan, Italy

[8] Uppsala Univ, Dept Genet Immunol & Pathol, Uppsala, Sweden

来源：

SCIENCE | 2015年 / 350卷 / 6262期

基金：

欧洲研究理事会;

关键词：

BLOOD-BRAIN-BARRIER;

D O I：

10.1126/science.aad0135

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In healthy individuals, the intestinal microbiota cannot access the liver, spleen, or other peripheral tissues. Some pathogenic bacteria can reach these sites, however, and can induce a systemic immune response. How such compartmentalization is achieved is unknown. We identify a gut-vascular barrier (GVB) in mice and humans that controls the translocation of antigens into the bloodstream and prohibits entry of the microbiota. Salmonella typhimurium can penetrate the GVB in a manner dependent on its pathogenicity island (Spi) 2-encoded type III secretion system and on decreased beta-catenin-dependent signaling in gut endothelial cells. The GVB is modified in celiac disease patients with elevated serum transaminases, which indicates that GVB dismantling may be responsible for liver damage in these patients. Understanding the GVB may provide new insights into the regulation of the gut-liver axis.

引用

页码：830 / 834

页数：5

共 20 条

[1]

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota [J].