Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC

被引：117

作者：

Liu, Sujun ^{[1
]}

Luo, Xun ^{[1
]}

Li, Daxu ^{[1
]}

Zhang, Jie ^{[1
]}

Qiu, DunLian ^{[1
]}

Liu, Wei ^{[1
]}

She, Liang ^{[1
]}

Yang, Zhirong ^{[1
]}

机构：

[1] Sichuan Univ, Coll Life Sci, Minist Educ, Key Lab Bioresources & Ecoenvironm, Chengdu 610064, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2006年 / 6卷 / 09期

关键词：

flavone; Cirsium root; tumor inhibition; immune regulation;

D O I：

10.1016/j.intimp.2006.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The purpose of these experiments is to study the effects of flavone from Cirsium japonicum DC (FLCJ) on tumor activity and on the regulation of the immune response in mice with S180 and H22 tumors. Pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone are two major components of FLCJ. FLCJ, pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone can inhibit the growth of the implanted tumors S 180 and H22 and promote cellular and humoral immune responses. FLCJ is stronger than Pectolinarin and 5, 7-dihydroxy-6, 4'-dimethoxyflavone in inhibiting tumors and promoting immune response significantly. Our results indicated that the tumor inhibition of FLCJ had close relation with its regulation of the immune response Furthermore, this tumor inhibition by FLCJ may activate the innate immune system, which would be expected as a potential anti-tumor drug. (c) 2006 Elsevier B.V All rights reserved.

引用

页码：1387 / 1393

页数：7

共 17 条

[1]

Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio [J].

Bhattacharyya, A ;

Mandal, D ;

Lahiry, L ;

Sa, G ;

Das, T .

CANCER LETTERS, 2004, 209 (02) :147-154

[2]

Chen YC, 2004, INT J ONCOL, V25, P661

[3]

CHEO IPJ, 1995, PHYTOCHEMISTRY, V39, P2612

[4]

GAN L, 2001, J WEI SHENG YANGJIU, V30, P33

[5]

GE LL, 1999, CHIN J INTEGR MED, V19, P152

[6]

GU YC, 1992, ZHONG GUO ZHONG YI Y, V17, P4892

[7]

[黄晓桃 Huang Xiaotao], 2004, [中国药理学通报, Chinese Pharmacological Bulletin], V20, P79

[8]

ISHIDA H, 1987, CHEM PHARM BULL, V35, P861

[9]

NOBUHIRO O, 2002, INT IMMUNOPHARMACOL, V2, P357

[10]

SHU S, 1997, J AM ASS, V278, P11

← 1 2 →