A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

被引：22

作者：

Allen, Naomi E. ^{[1
]}

Roddam, Andrew W. ^{[1
]}

Sieri, Sabina ^{[2
]}

Boeing, Heiner ^{[3
]}

Jakobsen, Marianne Uhre ^{[4
]}

Overvad, Kim ^{[4
]}

Tjonneland, Anne ^{[5
]}

Halkjaer, Jytte ^{[5
]}

Vineis, Paolo ^{[6
,7
]}

Contiero, Paolo ^{[8
]}

Palli, Domenico ^{[9
]}

Tumino, Rosario ^{[10
]}

Mattiello, Amalia ^{[11
]}

Kaaks, Rudolf ^{[12
]}

Rohrmann, Sabine ^{[12
]}

Trichopoulou, Antonia ^{[13
]}

Zilis, Demosthenes ^{[13
]}

Koumantaki, Yvoni ^{[13
]}

Peeters, Petra H. ^{[14
]}

Bueno-de-Mesquita, H. Bas ^{[15
]}

Barricarte, Aurelio ^{[16
]}

Rodriguez, Laudina ^{[17
]}

Dorronsoro, Miren

Sanchez, Maria-Jose ^{[18
]}

Dolores Chirlaque, Maria ^{[19
]}

Esquius, Laura ^{[20
]}

Manjer, Jonas ^{[21
]}

Wallstrom, Peter ^{[22
]}

Ljungberg, Borje ^{[23
]}

Hallmans, Goran ^{[24
]}

Bingham, Sheila ^{[25
]}

Khaw, Kay-Tee ^{[26
]}

Boffetta, Paolo ^{[27
]}

Norat, Teresa ^{[7
]}

Mouw, Traci ^{[7
]}

Riboli, Elio ^{[7
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[2] Ist Nazl Tumori, Fdn IRCCS, Nutr Epidemiol Unit, I-20133 Milan, Italy

[3] German Inst Human Nutr, Potsdam, Germany

[4] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Univ Turin, Dept Biomed Sci, Turin, Italy

[7] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[8] Ist Nazl Tumori, Fdn IRCCS, Canc Registry & Environm Epidemiol, I-20133 Milan, Italy

[9] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[10] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[11] Univ Naples Federico 2, Dipartimento Med Clin & Sperimentale, Naples, Italy

[12] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany

[13] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[14] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[15] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands

[16] Publ Hlth Inst Navarra, Pamplona, Spain

[17] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[18] Andalusian Sch Publ Hlth Granada, Granada, Spain

[19] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[20] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[21] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[22] Lund Univ, Dept Clin Sci, Nutr Epidemiol Res Grp, Malmo, Sweden

[23] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[24] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[25] Univ Cambridge, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[26] Univ Cambridge, Dept Gerontol, Cambridge, England

[27] Int Agcy Res Canc, F-69372 Lyon, France

来源：

INTERNATIONAL JOURNAL OF CANCER | 2009年 / 125卷 / 04期

基金：

英国医学研究理事会;

关键词：

macronutrients; renal cell carcinoma; diet; EPIC; prospective; PHYSICAL-ACTIVITY; KIDNEY CANCER; ENERGY-INTAKE; RISK-FACTORS; DIET; CALIBRATION; VITAMIN; PROTEIN;

D O I：

10.1002/ijc.24447

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Previous case-control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow-up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women. (C) 2009 UICC

引用

页码：982 / 987

页数：6

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