Role of mitochondrial membrane permeabilization in apoptosis and cancer

被引：239

作者：

Henry-Mowatt, J

Dive, C

Martinou, JC

James, D

机构：

[1] Univ Geneva, Dept Cell Biol, CH-1211 Geneva 4, Switzerland

[2] Paterson Inst Canc Res, Cellular & Mol Pharmacol Grp, Manchester M20 4BX, Lancs, England

来源：

ONCOGENE | 2004年 / 23卷 / 16期

关键词：

mitochondria; cancer therapy; apoptosis; Bcl-2; family; permeability transition pore;

D O I：

10.1038/sj.onc.1207534

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The release of proteins from the intermembrane space of mitochondria is one of the pivotal events in the apoptotic process, which can lead to the activation of caspases and the ultimate demise of the cell. How these proteins exit the mitochondria is still a matter of intense debate. Here, we discuss the possible mechanisms behind the release of apoptogenic proteins, the ways in which cancer cells subvert these mechanisms, and the therapeutic regimens that aim to promote the timely loss of integrity of the outer mitochondrial membrane.

引用

收藏

页码：2850 / 2860

页数：11

相关论文

共 140 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].

Adams, JM ;

Cory, S .

SCIENCE, 1998, 281 (5381) :1322-1326

[2] Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region [J].

Adrain, C ;

Slee, EA ;

Harte, MT ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20855-20860

[3] Bcr-Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity [J].

AmaranteMendes, GP ;

Jascur, T ;

Nishioka, WK ;

Mustelin, T ;

Green, DR .

CELL DEATH AND DIFFERENTIATION, 1997, 4 (07) :548-554

[4]

Amundson SA, 2000, CANCER RES, V60, P6101

[5] Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells [J].

Antonsson, B ;

Montessuit, S ;

Sanchez, B ;

Martinou, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (15) :11615-11623

[6] Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization [J].

Arnoult, D ;

Gaume, B ;

Karbowski, M ;

Sharpe, JC ;

Cecconi, F ;

Youle, RJ .

EMBO JOURNAL, 2003, 22 (17) :4385-4399

[7] Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ [J].

Arnt, CR ;

Chiorean, MV ;

Heldebrant, MV ;

Gores, GJ ;

Kaufmann, SH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (46) :44236-44243

[8] In self-defence: Hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death [J].

Azoulay-Zohar, H ;

Israelson, A ;

Abu-Hamad, S ;

Shoshan-Barmatz, V .

BIOCHEMICAL JOURNAL, 2004, 377 :347-355

[9]

Banerjee D, 2001, Curr Opin Investig Drugs, V2, P574

[10] Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Δψm) in pancreatic R1Nm5F cells:: prevention by Bcl-2 [J].

Barbu, A ;

Welsh, N ;

Saldeen, J .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 190 (1-2) :75-82

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