Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy

被引：58

作者：

Hartono, Choli ^{[1
,2
]}

Chung, Miriam ^{[1
,2
]}

Kuo, Sheng F. ^{[3
]}

Seshan, Surya V. ^{[4
]}

Muthukumar, Thangamani ^{[1
,2
]}

机构：

[1] Rogosin Inst, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Div Nephrol & Hypertens, New York, NY USA

[3] New York Hosp Queens, Flushing, NY USA

[4] Weill Cornell Med Coll, Dept Pathol, New York, NY USA

来源：

JOURNAL OF NEPHROLOGY | 2014年 / 27卷 / 01期

关键词：

Bortezomib; Membranous nephropathy; Nephrotic syndrome; Proteasome inhibitor; DEPLETION; RITUXIMAB;

D O I：

10.1007/s40620-013-0028-x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adults. The nephrotic syndrome due to idiopathic membranous nephropathy is often resistant to glucocorticosteroids and requires an alkylating agent such as chlorambucil or cyclophosphamide to induce remission. Recent studies illustrate that antibodies against the autoantigen M-type phospholipase A2 receptor contribute to a vast majority but not all cases of idiopathic membranous nephropathy. Herein, we report a patient with nephrotic syndrome due to membranous nephropathy that was resistant to 6 months of therapy with ramipril and high-dose glucocorticosteroids but responded to a single cycle of bortezomib infusion.

引用

页码：103 / 106

页数：4

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