The centrosome cycle

被引：131

作者：

Meraldi, P ^{[1
]}

Nigg, EA ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany

来源：

FEBS LETTERS | 2002年 / 521卷 / 1-3期

关键词：

centrosome duplication; centrosome maturation; centrosome separation; centriole disorientation; protein phosphorylation; proteolysis;

D O I：

10.1016/S0014-5793(02)02865-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：9 / 13

页数：5

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